Estrogen and the Aging Primate Brain

近年来，这种跨机构的合作努力的进展集中在持续的定量形态学分析在大脑中的行为特征的主题与雌激素状态。例如，在最近的一项研究中，Crimins et.等人（2017）使用定量连续切片免疫电子显微镜检测雌二醇给药对卵巢切除的年轻和老年猴背外侧前额叶皮层中G蛋白偶联雌激素受体1（GPER 1）表达的影响。GPER1分布在广泛的细胞成分中，但通常没有作为年龄，激素治疗或认知状态的函数而有所不同。尽管如此，GPER1的代表性，特别是在突触是密切相关的突触密度，这表明GPER1定位于介导的强大影响的雌激素对突触可塑性。未来的研究有望进一步深入了解更年期和激素治疗对老年妇女认知健康的神经生物学影响。

Progress on this trans-institutional collaborative effort in recent years has focused on continued quantitative morphometric analysis in the brains of behaviorally characterized subjects in relation to estrogen status. In a recent study, for example, Crimins et. al. (2017) used quantitative serial section immunoelectron microscopy to test the effects of estradiol administration on the representation of G protein-coupled estrogen receptor 1 (GPER1) in the dorsolateral prefrontal cortex of ovariectomized young and aged monkeys. GPER1 was distributed across a wide range of cellular components, but generally failed to differ as a function of age, hormone treatment, or cognitive status. Nonetheless, GPER1 representation specifically at the synapse was closely associated with synaptic density, suggesting that GPER1 is positioned to mediate a powerful influence of estrogen on synaptic plasticity. Future studies are expected to yield additional insight into the neurobiological implications of menopause and hormone treatment on womens cognitive health in aging.