Northeast Node of the National Drug Abuse Clinical Trials Network

 描述：我们建议建立NIDA临床试验网络(CTN)的一个新节点--横跨新罕布夏州、佛蒙特州和缅因州农村社区的东北节点。该节点将以达特茅斯学院为基础，与几个大型提供者网络合作，覆盖400多个成人和/或青少年普通医疗保健合作伙伴，一系列成瘾专业计划，以及一个全国性的行为健康管理护理合作伙伴。达特茅斯是这个节点的理想之地，因为它也是NIDA资助的技术和行为健康中心(CTBH)的所在地，CTBH是一个P30“卓越中心”，利用科学为基于技术(网络、移动)的治疗工具的开发、评估和战略实施提供信息，以针对物质使用障碍(SUDS)和相关问题(包括艾滋病毒风险行为和精神并发症)。CTBH由Lisa Marsch博士领导，她也将担任拟议的CTN节点的首席调查员。我们的团队通过提高专注于将技术应用于SUD和行为健康治疗的科学研究的质量、完成速度和影响而在该领域处于领先地位。我们的团队在SUD干预开发的所有阶段都拥有专业知识，从可行性、可接受性、有效性、功效-有效性、有效性(包括多点有效性试验)、成本效益以及在许多情况下的实施研究，包括成瘾和精神健康专科项目、医疗专科项目、医院、学校、刑事司法环境和初级保健。这项工作包括关于将SUD干预措施整合到农村卫生保健系统的开创性研究。这项工作是在广泛的人群中进行的，包括长期吸毒者、吸烟者、退伍军人、慢性疼痛患者、艾滋病毒高危人群以及同时患有肥皂泡和精神疾病的人。我们小组在青少年研究方面具有特殊专长，从筛查和评估、预防、治疗、康复支助和青少年护理协调--包括侧重于青少年中大麻使用和处方阿片类药物使用障碍的几个系列研究。这项建议的目的是(1)通过启动CTN的东北节点，将NIDA CTN扩展到农村地区的新州，从而扩大我们与初级保健和其他社区治疗合作伙伴在确定和实施针对肥胖症的及时和重要试验方面的合作；(2)支持和发展富有成效的研究议程，特别关注集中利用基于技术的工具和/或优先关注青年的CTN试验--既在东北节点内，也通过全国CTN社区内的领导和咨询角色；以及(3)发展和支持基础设施，以增强协同作用，支持CTBH和CTN之间的知识和资源的双向共享。这些活动将为关于农村保健系统中与物质使用相关的需求和优先事项以及各种社区系统中以技术为基础的干预措施的有效性的关键科学发现和见解提供信息。

 DESCRIPTION: We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 "Center of Excellence" that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectivenes, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth - both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.