Long-term metabolic effects of stress and antidepressants: a novel translational animal paradigm of drug-induced obesity

抗抑郁药是否导致了澳大利亚的肥胖流行？数百万澳大利亚人接受抗抑郁药治疗，这通常会导致体重增加。我们的研究表明，即使短暂接触抗抑郁药也会加剧长期压力下的体重增加。这一新知识代表了对抗抑郁药相关体重增加的理解的重大转变。在这个项目中，我们将研究在致肥环境中暴露于压力和抗抑郁药物后长期体重增加的机制。

Do antidepressants contribute to Australia's obesity epidemic? Millions of Australians are treated with antidepressants, which often causes weight gain. Our work shows that even brief exposure to antidepressants exacerbate body weight gain following exposure to chronic stress. This new knowledge represents a significant shift in the understanding of antidepressant-related weight gain. In this project we will study the mechanisms involved in long-term weight gain after exposure to stress and antidepressants in an obesogenic environment.