2/2 Ponce School of Medicine-Moffitt Cancer Center Partnership

项目摘要/摘要 庞塞健康科学大学(PHSU)和莫菲特癌症中心(MCC)已经建立了一个 牢固的工作关系建立在相互支持和互利的无缝沟通基础上。使用 合作伙伴资源和两个机构的重大承诺，我们已经建立了联合项目 加强基础和临床研究，丰富癌症外展，扩大癌症教育，创建 独特的拉美裔/拉丁裔(H/L)生物库，导致发展强大的网络和基础设施 这对于持续的长期合作以改善H/L人群的癌症预后是必要的。U54 伙伴关系的直接影响包括在H/L发现乳腺癌和肺癌的新突变 病人，招聘对可持续性和增长至关重要的新教员，以及84个社区外展 在佛罗里达(FL)和波多黎各(PR)为H/L开展教育活动。波多黎各的发展 生物库(PRBB)和临床研究人员的培训，在庞塞启动了25项临床干预试验， 展示通过伙伴关系实现的广泛影响。此外，伙伴关系还发挥了关键作用 在ACGME血液学/肿瘤学院士的重新认证中，在PR中建立了两个STEM 在MCC骨髓移植单位接受培训的研究员在PR中进行的细胞移植计划，以及在 在庞塞建立ACGME认可的外科住院医师，并在MCC进行外科肿瘤学轮换。 U54合作伙伴基金头4年的短期指标包括48名学生参与者，35名 发表同行评审稿，并在基金资助的29份稿件中提交。 我们对U54 PACHE更新的愿景是进一步发展和吸引师生参与癌症研究 直接影响FL和PR中H/L人群的精准医学研究。合作伙伴关系拥有 在服务不足的人群中充分实施精准医疗所必需的组件-生物库， 量化科学核心(QSC)以分析数据、文化敏感的外展材料、最新的专业知识 技术，以及强大的研究组合。续签U54合作伙伴关系的四个具体目标是 跟在后面。目标1：增加PHSU专注于基础/翻译研究的研究人员数量 并增加MCC癌症健康差异研究人员的数量。这是通过以下方式实现的 卵巢癌和乳腺癌的联合项目。目标2：进一步发展外联方案和研究工作 在华东师范大学和华中师范大学的H/L社区。一个流行病学项目将检查收到病毒的影响。 MC1R基因对个人防晒行为的影响。目标3：增加对基本的、翻译的 并通过建立QSC和进一步发展PRBB在H/L人群中进行临床研究。这个 将在庞塞医院制定MCC全面癌症护理协议，并由公共政策局利用，以促进 收集纸巾。目标4：在PHSU和PHSU提供全面和有组织的学生研究教育 和MCC，以促进H/L人群中癌症研究人员和临床医生的扩张和成功。

PROJECT SUMMARY/ABSTRACT The Ponce Health Sciences University (PHSU) and the Moffitt Cancer Center (MCC) have forged a strong working relationship founded on seamless communication with mutual support and benefits. With Partnership resources and significant commitment from both institutions, we have established joint programs enhancing basic and clinical research, enriching cancer outreach, expanding cancer education, and creating a unique Hispanic/Latino (H/L) Biobank, leading to the development of a robust network and infrastructure necessary for a sustained long-term collaboration to improve cancer outcomes in the H/L population. The U54 Partnership’s immediate impact includes the identification of new mutations in breast and lung cancer in H/L patients, recruitment of new faculty essential for sustainability and growth, and 84 community outreach educational activities for H/Ls in Florida (FL) and Puerto Rico (PR). The development of the Puerto Rico Biobank (PRBB) and the training of clinical researchers, with 25 clinical intervention trials activated in Ponce, demonstrate the broad impact realized through the Partnership. Furthermore the Partnership had a critical role in the ACGME re-accreditation of the Hematology/Oncology Fellowship in PR, in the establishment of two stem cell transplant programs in PR by fellows trained in the MCC Bone Marrow Transplant unit, and in the establishment of an ACGME-accredited surgical residency in Ponce with surgical oncology rotations at MCC. The short-term metrics of the first 4 years of the U54 Partnership grant include 48 student participants, 35 peer-reviewed manuscripts published, and 29 grants funded out of a total of 64 submitted. Our vision for the U54 PACHE renewal is to further grow and engage faculty and students in cancer precision medicine research that directly impacts the H/L populations in FL and PR. The Partnership has the requisite components to fully execute precision medicine in an underserved population—a biobank, quantitative science core (QSC) to analyze data, culturally sensitive outreach materials, expertise in the latest technologies, and a robust research portfolio. The four specific aims for the U54 Partnership renewal are the following. Aim 1: To increase the number of researchers at PHSU focused on basic/translational research in cancer and to augment the number of researchers in cancer health disparities at MCC. This is facilitated with joint projects in ovarian and breast cancer. Aim 2: To further develop outreach programs and research efforts in the H/L communities at both PHSU and MCC. An epidemiological project will examine the impact of receipt of MC1R genotypes on personal sun protection behaviors. Aim 3: To increase support for basic, translational and clinical research in the H/L population by establishing the QSC and further developing the PRBB. The MCC Total Cancer Care protocol will be developed in Ponce hospitals and leveraged by the PRBB to facilitate tissue collection. Aim 4: To provide comprehensive and structured student research education at both PHSU and MCC to facilitate the expansion and success of cancer researchers and clinicians in the H/L population.