SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

项目总结，总体 安全、有效的疫苗仍然是控制人类免疫缺陷病毒的最大希望 (艾滋病毒)大流行。由于起源于印度的恒河猴(Macaca Mulatta)与人类之间的相似性 免疫系统、疫苗开发以及其他控制艾滋病的方法 依赖于SIV和SHIV猕猴模型。对印度原产恒河猴的需求仍在持续 猕猴来支持这项工作。高效的国内育种计划，有效地管理生产良好 特色化动物，在生物医学研究中具有更高的实用性，提供了确保 为艾滋病疫苗开发和其他治疗和发病机制提供印度血统的恒河猴 学习。这项建议的目的是为具有遗传特征的特定病原体提供支持 免费的印度原产恒河猴艾滋病研究群体资源，于2001年在 俄勒冈州国家灵长类动物研究中心。

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development as well as other approaches for controlling AIDS are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Efficient domestic breeding programs, effectively managed to produce well characterized animals, with enhanced usefulness in biomedical research offer the best solution to ensuring the supply of Indian-origin rhesus macaques for AIDS vaccine development and other treatment and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.