ShEEP and LAMb Request for IVIS Imaging System

生物医学和康复研究越来越依赖于最先进的成像方式来 想象细胞、组织和器官。在VAPAHCS，我们的研究计划依赖于尖端成像 包括对退伍军人群体的阿尔茨海默病等重要疾病和障碍的研究， 创伤性脑损伤、癌症、自身免疫性疾病、退行性疾病、血管疾病、脊髓 肌肉、骨骼和肌腱的创伤性损伤。对于如此多的研究领域，疾病建模 随着成像系统的发展，实验疗法已经发生了革命性的变化 随着时间的推移对活体动物体内细胞的追踪。这种方法在VAPAHCS中得到了广泛应用 在过去的10年里，对于非侵入性疾病监测、干细胞等过程的分析 治疗，细胞移植，肿瘤生长，体内基因表达分析，免疫细胞跟踪，以及 神经发生，并且仍然是我们研究计划的一个关键因素。 Perkin/Elmer IVIS Spectrum in Vivo成像系统是一种顶级的研究仪器，它结合了 尖端技术、高质量和极佳的易操作性。这台仪器将取代一个 过时的版本，已有近十年的历史，尽管进行了例行维护，但仍经常失败。此外， 新系统的功能包括一个灵敏度更高的摄像头，提供更高的空间分辨率和 为的关键功能提供更强大的图像处理和分析的软件 生物发光成像(BLI)、荧光成像(FLI)、切伦科夫光、3D断层成像和 光谱分解。目前过时的设备每天使用长达10个小时，包括周末，由 VAPAHCS的调查人员。能够用新的和更新的系统替换我们过时和故障的系统 该系统将极大地促进和加速VAPAHCS的研究计划。我们已经概述了一个 监督新设备的使用和维护的行政程序，我们概述了一项计划 机构支持，为未来十年的设备服务提供资源。总体而言， 在活体成像系统中购买新的Perkin/Elmer IVIS Spectrum对于正在进行的 VAPAHCS的生物医学和康复研究，以便让调查人员继续在 处于各自领域研究的前沿，拥有最先进的设备。

Biomedical and rehabilitation research depends increasingly on state-of-the-art imaging modalities to visualize cells, tissues, and organs. At VAPAHCS, our research program that depends on cutting edge imaging includes the study of such important diseases and disorders for the Veteran population as Alzheimer's disease, traumatic brain injury, cancer, autoimmune disorders, degenerative disorders, vascular disease, spinal cord injury, and traumatic injuries to muscle, bone, and tendon. For so many lines of research, disease modeling and experimental therapeutics have been revolutionized by the development of imaging systems that allow for the tracking of cells in vivo in living animals over time. This approach has been used extensively at VAPAHCS for the past 10 years for the analysis of such processes as non-invasive disease monitoring, stem cell therapies, cell transplantation, tumor growth, in vivo gene expression analysis, immune cell tracking, and neurogenesis, and remains a critical element of our research program. The Perkin/Elmer IVIS Spectrum In Vivo Imaging System is a top-level research instrument that combines cutting edge technology with quality and exceptional ease of operation. This instrument will replace an outdated version that is almost ten years old and failing regularly despite routine maintenance. Furthermore, the new system features includes a camera of enhanced sensitivity providing increased spatial resolution and software that provides more powerful image processing and analysis for the key functionalities of Bioluminescence Imaging (BLI), Fluorescent Light Imaging (FLI), Cherenkov light, 3D tomography, and Spectral Unmixing. The current, outdated equipment is used up to 10 hours a day, including weekends, by investigators at VAPAHCS. The ability to replace our outdated and failing system with a new and updated system would greatly facilitate and accelerate the research program at VAPAHCS. We have outlined an administrative process to oversee the use and maintenance of the new equipment, and we outline a plan for institutional support to provide the resources for equipment service over the next ten years. Overall, the purchase of a new Perkin/Elmer IVIS Spectrum In Vivo Imaging System is critically important for the ongoing biomedical and rehabilitation research at VAPAHCS in order to allow investigators to continue to be at the forefront of research in their respective fields with access to state-of-the-art equipment.