Enhancing Intervention of Attenuated Psychosis Syndrome with M-Health Technology

“利用移动健康技术加强对减轻精神病综合征的干预” 7.项目摘要/摘要： 有一项世界性的运动，即对可能是前驱疾病的人群进行早期干预 弱化精神病综合征(APS)阶段，主要由澳大利亚、欧洲和北方的研究人员领导 美国(“北美前驱症状纵向研究/NAPLS)”在早期的亚洲网络中 精神病、台湾和新加坡已经开始解决被认为是前驱的人群。致我们的 知识，我们是第一个在亚洲中低收入国家开展APS研究的研究小组，以及 R21与上海精神卫生中心(SMHC)合作(1R21MH093294-01A1，Fogarty/NIMH， “将精神病前兆的调查扩大到不同的文化群体”)和R01“验证” 上海先兆和向精神病过渡的生物标记物“(第1版，MH，101052-01，NIMH)。R21 R01研究旨在早期识别APS及APS的危险因素。我们目前的提案，在 对NIH FOA(PAR-16-292)移动健康的响应：低收入和中等收入人群的技术和结果 国家(R21)，将重点针对神经认知功能-记忆和注意力-的早期干预努力 特别是使用移动健康技术。我们将开发和实施一款具有文化敏感性的智能手机 应用程序让APS患者参与改善神经认知和社会功能。我们的目标是工作 与SMHC的研究人员合作，建设他们的研究能力，建立可持续的APS 中国的纵向研究方案，为APS的早期干预奠定基础 技术该项目将分两个阶段完成：第一阶段(1-7个月)，开发和测试特定的 通过定性研究方法应用记忆注意资源和培训(SMART)-in-in 深度1：1访谈。阶段2(8-24月)，我们将首先研究智能可行性和用户参与度 采用混合方法设计。我们将对80名APS受试者(年龄18-45岁)进行初步研究。四十名受试者将 获得常规护理(RC)，与年龄、性别、临床症状匹配的40人将获得3年的附加SMART 除RC外，还需数月。在基线和3个月的随访中，所有受试者将在APP上完成问卷调查 对智能可行性和参与性的使用习惯和态度，以及Matrics认知电池 测试工作记忆和注意力的子测试。RC小组将提供他们的态度来解决 使用SMART的可能性。将在这两个时间点进行深入访谈，以交叉验证 从问卷中获得的结果。其次，我们将研究认知和社会功能的变化 随着时间的推移，小组内部和小组之间的设计。第三，我们致力于建立移动健康研究能力， 在授予时间内和之后，个人和组织级别。

“Enhancing Intervention of Attenuated Psychosis Syndrome with M-Health Technology” 7. Project Summary/Abstract: There is a worldwide movement in the early intervention of populations at the putatively prodromal or attenuated psychosis syndrome (APS) stage, led mainly by researchers in Australia, Europe, and North America (“North American Prodrome Longitudinal Studies/NAPLS). Within the Asian Network for Early Psychosis, Taiwan and Singapore have started to address the putatively prodromal population. To our knowledge, we are the first research group carrying out APS studies in a low-middle income country in Asia, an R21 in collaboration with the Shanghai Mental Health Center (SMHC) (1R21MH093294-01A1, Fogarty/NIMH, “Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups”), and an R01 “Validating Biomarkers for the Prodrome and Transition to Psychosis in Shanghai” (1 R01 MH 101052-01, NIMH). The R21 and R01 studies aim at early identification of APS and the risk factors of APS. Our current proposal, in response to the NIH FOA (PAR-16-292) Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21), will focus on early intervention effort targeting neurocognitive function-memory and attention in particular, using mHealth technology. We will develop and implement a culturally sensitive smart phone application to engage patients with APS in improving neurocognitive and social functioning. Our goal is to work collaboratively with researchers at the SMHC to build their research capacity in establishing a sustainable APS longitudinal program of research in China and to lay a foundation for APS early intervention with mHealth technology. This project will be completed in two phases: Phase 1 (Month 1-7), Develop and test the Specific Memory Attention Resource and Training (SMART) application through a qualitative research approach-in- depth 1:1 interviews. Phase 2 (Month 8-24), we will firstly examine SMART feasibility and user engagement with a mixed method design. We will conduct a pilot study of 80 APS subjects (age 18-45). Forty subjects will get routine care (RC) and 40 matched by age, gender, clinical symptoms will receive add-on SMART for 3 months in addition to RC. At baseline and 3-month follow-ups, all subjects will complete questionnaires on app use habits and attitudes towards SMART feasibility and engagement, and MATRICS Cognitive Battery subtests measuring working memory and attention. The RC group will provide their attitudes addressing the likelihood of using SMART. In-depth interviews will be conducted at both time points to cross-validate the findings obtained from the questionnaires. Secondly we will examine cognitive and social function changes over time with the within and between group design. Thirdly, we strive to build mHealth research capacity at individual and organization levels during and beyond grant time.