Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups

将精神病前兆的调查范围扩大到不同文化群体

• 批准号: 8456073
• 负责人: Huijun Li
• 金额: $ 11.88万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-06 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8456073
• 关键词: Adolescent; Affect; American; Applications Grants; Area; Asians; Australia; Biological; Blood specimen; Boston; Brain; Brain Diseases; Brain Injuries; Canada; Characteristics; China; Chinese People; Chronic; Clinical; Clinical assessments; Complement; Country; Data; Development; Diabetes Mellitus; Diagnostic; Diagnostics Research; Early Intervention; Early identification; Early treatment; Electroencephalography; England; Environment; Ethnic group; Europe; Event-Related Potentials; Foundations; Funding; Future; Gender; Genetic; Germany; Goals; Grant; Guidelines; Heart Diseases; Hong Kong; Impairment; Income; Individual; Intervention; Interview; Investigation; Israel; Japan; Language; Lead; Longevity; Longitudinal Studies; Low income; Measures; Medical center; Mental Health; Morbidity - disease rate; Movement; Neurocognitive; North America; Patients; Phase; Phenotype; Population; Population Study; Prevention; Prevention strategy; Preventive; Preventive Intervention; Procedures; Process; Process Measure; Program Development; Psychiatry; Psychotic Disorders; Public Health; Publications; Reporting; Research; Research Personnel; Research Training; Resources; Risk; Risk Factors; Risk Management; Role; Schizophrenia; Singapore; Staging; Structure; Switzerland; Symptoms; Syndrome; System; Techniques; Time; Training; Training Support; Translating; United States; World Health Organization; Youth; biopsychosocial; design; functional decline; high risk; improved; information processing; instrument; medical schools; mental health center; mental state; neuropsychological; novel strategies; programs; psychosocial; quality assurance; racial and ethnic; skills; skills training; social stigma; socioeconomics; therapy development; tool; treatment trial; young adult

The identification of people who are at risk of developing psychosis is central to the development of early intervention and prevention strategies for schizophrenia. There is a world-wide movement in the study of populations at the prodromal stage led by researchers in the United States, Australia, England, Canada, Germany, and Switzerland. It is important to understand the biopsychosocial processes that occur during the clinical high risk (CHR) phase. The North American Prodrome Longitudinal Study (NAPLS) has identified key clinical characteristics and predictors of CHR youth using a comprehensive assessment package encompassing psychosocial, biological, neuropsychological, and genetic components. This is critical because it informs development of early interventions for prevention of brain damage. However, the NAPLS study is limited to the North American subjects. The purpose of this project is to broaden the existing prodrome to psychosis study to populations in a different cultural and genetic pool to examine the important cultural differences in the manifestations of the symptoms and the predictors of the illness. The overall goal of this application is to design and initiate a sustainable CHR to psychosis longitudinal program of research in a low-middle income country. Specifically, we attempt to: 1. Assess potential research needs of the Shanghai Mental Health Center [SMHC], a World Health Organization designated researcher center for mental health, and 2. Help develop a program of research on the progression of schizophrenia from prodrome to psychosis. The preliminary study contains four major components: a) clinical assessment of prodromal subjects. For this aim, the Structured Interview for Prodromal Syndromes and Scale of Prodromal Symptoms (SIPS/SOPS) will be translated into the language of the subjects and subsequently validated; b) neurocognitive assessment with the MATRICS battery, c) stigma, and d) electrophysiological assessment using event related potentials. In addition, blood samples will be collected and stored for future analyses. Gender effects will be examined across the above aims. The study goals are consistent with the guidelines of the FOA Brain Disorders in the Developing World: Research Across the Lifespan (R21, PAR-11-031).

确定哪些人有发展成精神病的风险是制定精神分裂症早期干预和预防策略的核心。由美国、澳大利亚、英国、加拿大、德国和瑞士的研究人员领导的对前驱阶段人群的研究在世界范围内展开。了解发生在临床高危(CHR)阶段的生物心理社会过程是很重要的。北美前驱症状纵向研究(NAPLS)利用一套涵盖心理社会、生物、神经心理和遗传因素的综合评估方案，确定了青少年慢性阻塞性肺疾病的关键临床特征和预测因素。这是至关重要的，因为它为制定预防脑损伤的早期干预措施提供了信息。然而，NAPLS的研究仅限于北美受试者。该项目的目的是将精神病研究的现有先兆扩大到不同文化和遗传库中的人群，以检查症状表现和疾病预测因素方面的重要文化差异。这项申请的总体目标是设计和启动一个可持续的中低收入国家的慢性精神病纵向研究计划。具体地说，我们试图：1.评估上海精神卫生中心(SMHC)的潜在研究需求，该中心是世界卫生组织指定的精神健康研究中心；2.帮助开发一个关于精神分裂症从先兆到精神病进展的研究计划。初步研究包括四个主要部分：a)前驱症状受试者的临床评估。为此，前驱症状和前驱症状量表的结构化访谈(SIPS/SOPS)将被翻译成受试者的语言并随后进行验证：b)使用Matrics电池进行神经认知评估，c)耻辱，d)使用事件相关电位进行电生理评估。此外，还将收集和储存血液样本，以供将来分析。将对上述目标的性别影响进行审查。研究目标与《发展中世界的脑部疾病：跨寿命研究》(R21，PAR-11-031)的指导方针是一致的。

项目成果

Calculating individualized risk components using a mobile app-based risk calculator for clinical high risk of psychosis: findings from ShangHai At Risk for Psychosis (SHARP) program.

使用基于移动应用程序的风险计算器计算临床高风险精神病的个体化风险成分：上海精神病风险 (SHARP) 项目的研究结果。

• DOI: 10.1017/s003329171900360x
• 发表时间: 2019
• 期刊: Psychological Medicine
• 影响因子: 6.9
• 作者: Zhang TianHong;Xu LiHua;Li HuiJun;Woodberry Kristen A;Kline Emily R;Jiang Jian;Cui HuiRu;Tang YingYing;Tang XiaoChen;Wei YanYan;Hui Li;Lu Zheng;Cao LiPing;Li ChunBo;Niznikiewicz Margaret A;Shenton Martha E;Keshavan Matcheri S;Stone William S;Wang JiJun
• 通讯作者: Wang JiJun

Prodromal psychosis detection in a counseling center population in China: an epidemiological and clinical study.

中国咨询中心人群的前驱精神病检测：一项流行病学和临床研究

• DOI: 10.1016/j.schres.2013.11.039
• 发表时间: 2014-02
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Zhang T;Li H;Woodberry KA;Seidman LJ;Zheng L;Li H;Zhao S;Tang Y;Guo Q;Lu X;Zhuo K;Qian Z;Chow A;Li C;Jiang K;Xiao Z;Wang J
• 通讯作者: Wang J

Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.

前驱、首发和慢性精神病中的神经心理损伤：评估 RBANS 表现。

• DOI: 10.1371/journal.pone.0125784
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhang T;Li H;Stone WS;Woodberry KA;Seidman LJ;Tang Y;Guo Q;Zhuo K;Qian Z;Cui H;Zhu Y;Jiang L;Chow A;Tang Y;Li C;Jiang K;Yi Z;Xiao Z;Wang J
• 通讯作者: Wang J

A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China.

中国精神病临床高风险个体的两个独立样本的转化率、临床特征和结果预测因子的比较

• DOI: 10.1016/j.schres.2017.11.029
• 发表时间: 2018-07
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Li H;Zhang T;Xu L;Tang Y;Cui H;Wei Y;Tang X;Woodberry KA;Shapiro DI;Li C;Seidman LJ;Wang J
• 通讯作者: Wang J

Should repetitive Transcranial Magnetic Stimulation (rTMS) be considered an effective adjunctive treatment for auditory hallucinations in patients with schizophrenia?

重复经颅磁刺激（rTMS）是否应该被视为精神分裂症患者幻听的有效辅助治疗？

• DOI: 10.3969/j.issn.1002-0829.2013.04.007
• 发表时间: 2013
• 期刊: Shanghai archives of psychiatry
• 作者: Wang,Jijun;Xu,Yifeng
• 通讯作者: Xu,Yifeng