Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups

识别有精神病风险的人是制定精神分裂症早期干预和预防策略的核心。在美国、澳大利亚、英国、加拿大、德国和瑞士的研究人员领导下，对前驱期人群的研究正在世界范围内展开。重要的是要了解发生在临床高风险（高危）阶段的生物心理社会过程。北美前驱症状纵向研究（NAPLS）已经确定了关键的临床特征和预测因素，使用一个全面的评估包，包括社会心理，生物，神经心理和遗传成分。这是至关重要的，因为它为预防脑损伤的早期干预措施的发展提供了信息。然而，NAPLS研究仅限于北美受试者。该项目的目的是将现有的精神病前驱症状研究扩大到不同文化和遗传库中的人群，以检查症状表现和疾病预测因素的重要文化差异。本申请的总体目标是在中低收入国家设计和启动一个可持续的精神病纵向研究项目。具体来说，我们试图：1。评估上海精神卫生中心（SMHC）的潜在研究需求，该中心是世界卫生组织指定的精神卫生研究中心;帮助制定一个关于精神分裂症从前驱症状到精神病的进展的研究计划。初步研究包括四个主要组成部分：a）前驱受试者的临床评估。为此，将前驱症状结构化访谈和前驱症状量表（SIPS/SOPS）翻译成受试者的语言，随后进行验证; B）使用MATRICS成套测验进行神经认知评估，c）污名，以及d）使用事件相关电位进行电生理评估。此外，将采集并储存血液样本以供将来分析。将审查上述目标对性别的影响。研究目标与发展中国家的FOA脑疾病指南一致：终生研究（R21，PAR-11-031）。

The identification of people who are at risk of developing psychosis is central to the development of early intervention and prevention strategies for schizophrenia. There is a world-wide movement in the study of populations at the prodromal stage led by researchers in the United States, Australia, England, Canada, Germany, and Switzerland. It is important to understand the biopsychosocial processes that occur during the clinical high risk (CHR) phase. The North American Prodrome Longitudinal Study (NAPLS) has identified key clinical characteristics and predictors of CHR youth using a comprehensive assessment package encompassing psychosocial, biological, neuropsychological, and genetic components. This is critical because it informs development of early interventions for prevention of brain damage. However, the NAPLS study is limited to the North American subjects. The purpose of this project is to broaden the existing prodrome to psychosis study to populations in a different cultural and genetic pool to examine the important cultural differences in the manifestations of the symptoms and the predictors of the illness. The overall goal of this application is to design and initiate a sustainable CHR to psychosis longitudinal program of research in a low-middle income country. Specifically, we attempt to: 1. Assess potential research needs of the Shanghai Mental Health Center [SMHC], a World Health Organization designated researcher center for mental health, and 2. Help develop a program of research on the progression of schizophrenia from prodrome to psychosis. The preliminary study contains four major components: a) clinical assessment of prodromal subjects. For this aim, the Structured Interview for Prodromal Syndromes and Scale of Prodromal Symptoms (SIPS/SOPS) will be translated into the language of the subjects and subsequently validated; b) neurocognitive assessment with the MATRICS battery, c) stigma, and d) electrophysiological assessment using event related potentials. In addition, blood samples will be collected and stored for future analyses. Gender effects will be examined across the above aims. The study goals are consistent with the guidelines of the FOA Brain Disorders in the Developing World: Research Across the Lifespan (R21, PAR-11-031).