Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups

识别有患精神病风险的人是制定精神分裂症早期干预和预防策略的核心。在美国、澳大利亚、英国、加拿大、德国和瑞士的研究人员领导下，对处于前驱期的人口进行了世界性的研究。重要的是要了解发生在临床高风险（CHR）阶段的生物心理社会过程。北美前驱期纵向研究（NAPLS）通过综合评估包确定了CHR青年的关键临床特征和预测因素，包括社会心理、生物学、神经心理学和遗传成分。这是至关重要的，因为它为预防脑损伤的早期干预措施的发展提供了信息。然而，NAPLS研究仅限于北美的研究对象。该项目的目的是将现有的前驱症状到精神病的研究扩大到不同文化和基因库的人群，以检查在症状表现和疾病预测因素方面的重要文化差异。本应用程序的总体目标是设计和启动一个可持续的CHR到精神病的纵向研究计划在一个中低收入国家。具体来说，我们试图：1。2.评估上海市精神卫生中心（世界卫生组织指定的精神卫生研究中心）的潜在研究需求；帮助制定一项研究计划，研究精神分裂症从前驱症状到精神病的进展。初步研究包括四个主要组成部分：a)前驱症状受试者的临床评估。为此，前驱症状结构化访谈和前驱症状量表（SIPS/SOPS）将被翻译成受试者的语言并随后进行验证；b)使用matrix电池进行神经认知评估，c)污名化，d)使用事件相关电位进行电生理评估。此外，血液样本将被收集和储存以供将来分析。性别影响将在上述目标中加以审查。研究目标与FOA在发展中国家的脑部疾病的指导方针是一致的：整个生命周期的研究（R21, PAR-11-031）。

The identification of people who are at risk of developing psychosis is central to the development of early intervention and prevention strategies for schizophrenia. There is a world-wide movement in the study of populations at the prodromal stage led by researchers in the United States, Australia, England, Canada, Germany, and Switzerland. It is important to understand the biopsychosocial processes that occur during the clinical high risk (CHR) phase. The North American Prodrome Longitudinal Study (NAPLS) has identified key clinical characteristics and predictors of CHR youth using a comprehensive assessment package encompassing psychosocial, biological, neuropsychological, and genetic components. This is critical because it informs development of early interventions for prevention of brain damage. However, the NAPLS study is limited to the North American subjects. The purpose of this project is to broaden the existing prodrome to psychosis study to populations in a different cultural and genetic pool to examine the important cultural differences in the manifestations of the symptoms and the predictors of the illness. The overall goal of this application is to design and initiate a sustainable CHR to psychosis longitudinal program of research in a low-middle income country. Specifically, we attempt to: 1. Assess potential research needs of the Shanghai Mental Health Center [SMHC], a World Health Organization designated researcher center for mental health, and 2. Help develop a program of research on the progression of schizophrenia from prodrome to psychosis. The preliminary study contains four major components: a) clinical assessment of prodromal subjects. For this aim, the Structured Interview for Prodromal Syndromes and Scale of Prodromal Symptoms (SIPS/SOPS) will be translated into the language of the subjects and subsequently validated; b) neurocognitive assessment with the MATRICS battery, c) stigma, and d) electrophysiological assessment using event related potentials. In addition, blood samples will be collected and stored for future analyses. Gender effects will be examined across the above aims. The study goals are consistent with the guidelines of the FOA Brain Disorders in the Developing World: Research Across the Lifespan (R21, PAR-11-031).