A Psychobiological Follow-up Study of Transition from Prodrome to Early Psychosis
从前驱症状到早期精神病转变的心理生物学随访研究
基本信息
- 批准号:9789368
- 负责人:
- 金额:$ 58.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescent and Young AdultAgeAge of OnsetAmericanAsiaAsiansAustraliaBiologicalBiological AssayBiological MarkersBiological ProcessBrainChinaClinicalClinical TrialsCognitiveCollaborationsCommunity Health EducationDataData CollectionDiffuseDiffusion Magnetic Resonance ImagingEarly InterventionEuropeEvent-Related PotentialsEvolutionFamily memberFloridaFollow-Up StudiesFoundationsFunctional Magnetic Resonance ImagingGoalsGrantHospitalsIndividualInstitutesInterventionJointsLiteratureLongevityLongitudinal StudiesMagnetic Resonance ImagingMassachusettsMeasuresMedialMemoryMental HealthMovementMyelinNational Institute of Mental HealthNatureNeurocognitionNeurocognitiveNorth AmericaOutcomeParahippocampal GyrusParticipantPatientsPharmaceutical PreparationsPhasePrefrontal CortexPreventive InterventionProcessPsychotic DisordersResearchResearch PersonnelResearch TrainingRestRiskRisk FactorsRoleSchizophreniaSingaporeSiteSocial FunctioningSolidStructureSurveysSymptomsTaiwanTechnologyTestingTimeTrainingTraining and EducationUnited States National Institutes of HealthUniversitiesVerbal LearningWaterWorkWorld Health Organizationbasebiopsychosocialclinical biomarkersdisabilityfollow up assessmentfollow-upgray matterhigh riskhigh risk populationimprovedlow and middle-income countriesmedical schoolsmental health centerneocorticalnervous system disorderneuroinflammationnovelpredictive markerpreferenceprocessing speedprogramspsychobiologicpsychosocialresponsesocialsocial stigmavirtualwhite matter
项目摘要
7. Project Summary/Abstract:
There is a worldwide movement in the early intervention for adolescents and young adults appearing to
develop early signs of psychosis or described as at clinical high risk (CHR) for psychosis, led mainly by
researchers in Australia, Europe, and North America. Within the Asian Network for Early Psychosis, Taiwan
and Singapore have started to address the CHR population. To our knowledge, we are the first research group
carrying out CHR studies in a low-middle income country in Asia. Since 2012, supported by NIMH/Fogarty
1R21MH093294-01A1 and an NIMH R01 MH101052-01, we have worked closely with the Shanghai Mental Health
Center (SMHC), to develop a CHR research program in Shanghai, China. The completed R21 and on-going
R01 projects aim at identification of the risk factors for CHR conversion over approximately one year. In our
current proposal, in response to NIH FOA PAR-14-332, Global Brain and Nervous System Disorders Research
across the Lifespan (R01), we will continue to enhance research capacity building at SMHC, and
collaboratively carry out an extensive follow-up study of clinical outcomes such as conversion to psychosis and
level of disability, and we will evaluate the evolution of biomarkers such as event related potentials, resting
state functional magnetic resonance imaging (MRI), white matter as assessed by diffusion tensor imaging MRI,
and neurocognition. We will follow-up 300 well characterized CHR and Healthy Control (HC) participants
between the ages of 15-45 for two more follow-up assessments. The longitudinal nature of the project is novel
in China and worldwide as this will be the first study to comprehensively examine biopsychosocial parameters
predictive of psychosis conversion and illness progression for up to 6 years, including two new follow-ups of
the biomarkers (4 assessments including baseline). Moreover, unlike many studies in the West, virtually 100%
of the participants are psychotropically naïve when they enter the study, and the assessments are done at one
site (SMHC), reducing confounds associated with medications and multiple sites. Our goal is to work
collaboratively with researchers at the SMHC to establish a sustainable CHR longitudinal program of research
in China and to lay a solid foundation for CHR early intervention.This project aims to: 1). Develop predictors for
conversion to psychosis, 2). Investigate clinical and biomarker progression in CHR, 3). Demonstrate an
association between clinical features, biological measures and disability in CHR, and 4). Explore the feasibility
of early intervention with CHR subjects. Capacity building and research training will be conducted during and
beyond the proposed project to facilitate sustainable research at SMHC.
7.项目概要/摘要:
有一个世界性的运动,在早期干预的青少年和年轻人出现,
出现精神病的早期体征或被描述为精神病的临床高风险(CRD),主要由以下因素导致
研究人员在澳大利亚,欧洲和北美。亚洲早期精神病网络(Asian Network for Early Psychosis)
和新加坡已经开始解决这一问题。据我们所知,我们是第一个
在亚洲的一个中低收入国家开展可持续发展研究。自2012年以来,由NIMH/Fogarty支持
1 R21 MH 093294 - 01 A1和NIMH R 01 MH 101052 -01,我们与上海市精神卫生局密切合作,
中心(SMHC),在中国上海开发一个可持续发展研究项目。已完成的R21和正在进行的
R 01项目的目的是在大约一年的时间内查明转用生物燃料的风险因素。在我们
目前的提案,响应NIH FOA PAR-14-332,全球脑和神经系统疾病研究
在整个生命周期(R 01),我们将继续加强SMHC的研究能力建设,
合作开展临床结果的广泛随访研究,如转化为精神病,
残疾水平,我们将评估生物标志物的演变,如事件相关电位,静息电位,
状态功能磁共振成像(MRI),通过扩散张量成像MRI评估的白色物质,
和神经认知我们将随访300名特征良好的健康对照(HC)参与者
年龄在15-45岁之间,进行两次后续评估。该项目的纵向性质是新颖的
因为这将是第一项全面检查生物心理社会参数的研究,
预测精神病转换和疾病进展长达6年,包括两次新的随访,
生物标志物(包括基线在内的4次评估)。此外,与西方的许多研究不同,
的参与者在进入研究时是精神病幼稚的,评估是在一个
临床试验机构(SMHC),减少与药物和多个部位相关的混淆。我们的目标是
与SMHC的研究人员合作,建立一个可持续的纵向研究计划
在中国的研究,为早期干预打下坚实的基础。本项目旨在:1)。开发预测器
转化为精神病,2)。研究胰腺癌的临床和生物标志物进展,3)。表现出
临床特征、生物学指标和残疾之间的相关性,以及4)。探讨可否
早期干预的可能性。能力建设和研究培训将在期间进行
除了拟议的项目,以促进SMHC的可持续研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Huijun Li其他文献
Huijun Li的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Huijun Li', 18)}}的其他基金
Enhancing Intervention of Attenuated Psychosis Syndrome with M-Health Technology
利用移动健康技术加强对弱化精神病综合征的干预
- 批准号:
9341776 - 财政年份:2017
- 资助金额:
$ 58.34万 - 项目类别:
Identifying mechanisms of response to therapeutic intervention in clinical high risk (CHR) for psychosis: a bridge to treatment
确定精神病临床高危(CHR)治疗干预的反应机制:治疗的桥梁
- 批准号:
10538935 - 财政年份:2016
- 资助金额:
$ 58.34万 - 项目类别:
A Psychobiological Follow-up Study of Transition from Prodrome to Early Psychosis
从前驱症状到早期精神病转变的心理生物学随访研究
- 批准号:
9202218 - 财政年份:2016
- 资助金额:
$ 58.34万 - 项目类别:
A Psychobiological Follow-up Study of Transition from Prodrome to Early Psychosis
从前驱症状到早期精神病转变的心理生物学随访研究
- 批准号:
10011832 - 财政年份:2016
- 资助金额:
$ 58.34万 - 项目类别:
Identifying mechanisms of response to therapeutic intervention in clinical high risk (CHR) for psychosis: a bridge to treatment
确定精神病临床高危(CHR)治疗干预的反应机制:治疗的桥梁
- 批准号:
10701018 - 财政年份:2016
- 资助金额:
$ 58.34万 - 项目类别:
Validating Biomarkers for the Prodrome and Transition to Psychosis in Shanghai
在上海验证前驱症状和向精神病转变的生物标志物
- 批准号:
8733754 - 财政年份:2013
- 资助金额:
$ 58.34万 - 项目类别:
Validating Biomarkers for the Prodrome and Transition to Psychosis in Shanghai
在上海验证前驱症状和向精神病转变的生物标志物
- 批准号:
8547471 - 财政年份:2013
- 资助金额:
$ 58.34万 - 项目类别:
Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups
将精神病前兆的调查范围扩大到不同文化群体
- 批准号:
8456073 - 财政年份:2012
- 资助金额:
$ 58.34万 - 项目类别:
Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups
将精神病前兆的调查范围扩大到不同文化群体
- 批准号:
8210870 - 财政年份:2012
- 资助金额:
$ 58.34万 - 项目类别:
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors
开发和测试针对青少年和青年儿童癌症幸存者的文化定制移动健康和社交媒体体育活动干预
- 批准号:
10736526 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别:
Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors
试点项目 1:为农村青少年和青年癌症幸存者搭建生殖保健桥梁
- 批准号:
10762146 - 财政年份:2023
- 资助金额:
$ 58.34万 - 项目类别: