2017 Mechanisms of Membrane Transport Gordon Research Conference and Gordon Research Seminar

项目摘要 离子、溶质、营养物质、废物以及必需分子在细胞内的运动 膜是由转运蛋白介导的。离子通道专门用于传导带电离子，例如 如Na+、K+和Cl-，从而建立和调节电和化学信号， 细胞之间的通信，是中枢神经系统的基本特征。运输商 更多样化的基质概况，包括营养物的输入和废物的输出， 异生物质例如，神经递质转运蛋白控制突触信号传导，而溶质转运蛋白和 肾脏和消化系统中的离子通道协同作用以调节血清离子浓度。一起 通道和转运蛋白是细胞内稳态和细胞外基质的生理功能的关键参与者。 有机体转运蛋白的功能障碍直接导致中枢神经系统的一系列疾病 在肠道和肾脏中。其中包括巴特综合征，糖尿病视网膜病变，自闭症，注意力 缺陷多动症和抑郁症。膜转运机制研究的使命是 推进离子通道和转运蛋白的结构，机制和生理的理解 因此，我们可以更好地阐明疾病的分子基础并制定治疗策略。一 戈登研究研讨会将由年轻的研究人员和学员在前两天举办， GRC将进一步促进两个NIH培训重点，即职业选择和严谨性的讨论， 科学的可重复性。为了实现这一目标，我们将汇集不同的科学家骨干， 该领域的最前沿，以展示和比较结果，讨论新闻想法，并建立合作， 紧张和高度集中的环境。

Project Summary The movement of ions, solutes, nutrients, waste products as well as essential molecules across cell membranes is mediated by transport proteins. Ion channels specialize in the conduction of charged ions, such as Na+, K+ and Cl-, thereby establishing and modulating the electric and chemical signals that facilitate communications between cells and is an essential feature of the central nervous system. Transporters have more diverse substrate profiles that include the import of nutrients and the export of waste products and xenobiotics. For example, neurotransmitter transporters control synaptic signaling while solute transporters and ion channels in the kidney and digestive system act in concert to regulate serum ion concentrations. Together channels and transporters are critical players in cellular homeostasis and the physiological functioning of an organism. Dysfunction of transport proteins directly leads to a spectrum of diseases in the central nervous systems and in the gut and kidney. Among these are Barter’s syndrome, diabetic retinopathy, autism, attention deficit hyperactivity disorder, and depression. The mission of the Mechanisms of Membrane Transport GRC is to advance the understanding of ion channels and transporters at the structural, mechanistic and physiological levels so that we may better illuminate the molecular basis of diseases and develop therapeutic strategies. A Gordon Research Seminar will be organized by young investigators and trainees in the two days prior to the GRC and will serve to further two NIH training priorities of discussion of career options and rigor and reproducibility in science. To achieve this goal, we will bring together a diverse cadre of scientists at the forefront of the field to present and compare results, discuss news ideas and establish collaborations in an intense and highly focused environment.