Archiving the Complete Data Set from the Oregon Youth Substance Use Project.

摘要 拟议项目的总体目标是将来自俄勒冈州的最新评估存档 青少年物质使用项目（OYEARS; RO 1DA 10767; RC 2DA 28793）。OYEARS研究始于1998年， 在一个工人阶级社区的一个学区内招募了1075名一年级到五年级的学生， 西俄勒冈州。参与者代表了学区的所有学生。队列序贯 采用大约每年评估一次的设计，在三年内跟踪这五个年级的队列。 发育期，儿童期，青春期和成年期。参与者、家长和老师 从一年级到五年级，每年进行一次评估， 消耗还获得了学校记录，并记录了人口普查区。2012年，我们将所有 从幼儿期到高中后一年的OYESTA数据与全国成瘾和艾滋病毒数据 档案计划（NAHDAP）在大学间政治和社会研究联盟在 密歇根大学（ICPSR），我们已经收集了该日期。我们现在要求资金来完成 存档过程，添加在成年初期收集的背景、生物和遗传数据， OYESTA的参与者年龄在19-26岁之间。具体目标是：（1）存档20-22岁参与者的数据 评估包括（a）20-22奥尔兹的诊断访谈，包括症状和DSM-IV 诊断，（B）来自Trier社会压力测试的数据（Kirschbaum等，1993年），包括皮质醇水平 随着时间的推移，影响评级和心率随着时间的推移，以及（c）参与者和家长问卷。（二） 主要在两个队列（第2和第3队列）中存档20-22岁受试者的数据 T1分级; n = 403）。这些数据包括与压力/奖励相关的候选基因的多态性 途径和HPA轴的功能，与压力相关的RNA数据，以及两次访谈的结果， 生活事件和困难时间表（LEDS; Brown & Harris，1978），以评估事件（情景压力）， 困难（慢性压力）在过去的一年和儿童经历和护理评估（CECA; Bifulco， 例如，1994年），以评估反感，忽视和虐待的童年。(3)20 - 26岁时收集的存档数据 评估新型烟草/尼古丁产品的使用和对使用的认知（a）两份问卷 评估，间隔11个月，和（B）与那些谁使用的微环境评估采访， 至少试用一种产品两次，或在两次评估之间改变其用途;以及（c）时间线随访 与这些参与者一起评估双重用途和使用顺序，以及（4）通过添加 家长和参与者问卷调查数据，来自最年轻的高中毕业后一年的评估 队列。由此产生的完整的OYEARS数据集的存档将使未来的合格的研究人员， 调查一个有代表性的工人阶级从一年级到26岁使用物质的病因 通过利用这个丰富的多源、多层次数据阵列，

ABSTRACT The overarching goal of the proposed project is to archive the most recent assessments from the Oregon Youth Substance Use Project (OYSUP; RO1DA10767; RC2DA28793). The OYSUP study began in 1998, with the recruitment of 1075 first through fifth graders within a single school district in a working class community in Western Oregon. Participants were representative of all students in the school district. A cohort sequential design with approximately annual assessments was used to follow these five grade cohorts over three developmental periods, childhood, adolescence, and emerging adulthood. Participants, parents and teachers were assessed annually from the 1st through the 5th grade through one-year post-high school, with minimal attrition. School records were also obtained and census blocks were recorded. In 2012, we archived all OYSUP data from early childhood through one-year post high school with the National Addiction & HIV Data Archive Program (NAHDAP) at the Inter-University Consortium for Political and Social Research at the University of Michigan (ICPSR) that we had collected by that date. We are now asking for funding to complete the archiving process, adding contextual, biological and genetic data collected in emerging adulthood when OYSUP participants were aged 19-26. The specific aims are: (1) Archive data from the age 20-22 participant assessments including (a) the diagnostic interview with 20-22 year olds, including symptoms and DSM-IV diagnoses, (b) data from the Trier Social Stress Test (Kirschbaum et al., 1993), including levels of cortisol across time, affect ratings and heart rate across time, and (c) the participant and parent questionnaires. (2) Archive data from 20-22 year old participants in primarily two cohorts (cohorts who were in the 2nd and 3rd grade at T1; n = 403). These data include polymorphisms of candidate genes related to the stress/reward pathway and the functioning of the HPA axis, RNA data related to stress, and the results of two interviews, the Life Events and Difficulty Schedule (LEDS; Brown & Harris, 1978), to assess events (episodic stress) and difficulties (chronic stress) over the past year and the Child Experiences and Care assessment (CECA; Bifulco, et al., 1994) to assess antipathy, neglect, and abuse in childhood. (3) Archive data collected at ages 20 – 26 assessing novel tobacco/nicotine product use and cognitions regarding use from (a) two questionnaire assessments, 11 months apart, and (b) an interview assessing the micro-context of use with those who had tried a product at least twice, or changed their use between assessments; and (c) a Time Line Follow-Back with these participants to assess dual use and order of use, and (4) Complete the archived data set by adding parent and participant questionnaire data from the one-year post-high school assessment for the youngest cohort. The resulting archive of the complete OYSUP data set will enable future qualified researchers to investigate the etiology of substance use from first grade through age 26 in a representative working class sample by drawing on this rich array of multi-source, multi-level data.