Translational Research Technologies Core

项目总结 解决新英格兰北部大部分农村人口的健康问题，并建立 研究能力，迫切需要整合临床和转化性研究基础设施 成为一个网络，将缅因州医疗中心和 位于新英格兰北部的佛蒙特大学临床与翻译研究网络(NNE-CTR)。 NNE-CTR的翻译研究技术核心(TRTC)的目标是为 通过Cobre、INBRE、 在过去几年中提供了机构和其他形式的支持。TRTC将提供访问 仪器、专业知识和其他对临床和转化性研究的成功至关重要的资源 NNE-CTR调查人员。这些资源包括基因组的基础设施和技术专长， 表观遗传学、蛋白质组学、细胞和组织分析以及临床和翻译基因组学。除了提供 基础设施、仪器设备和专业知识，TRTC将为调查人员提供教育和培训 关于对其研究活动的成功至关重要的现有技术和新兴技术。这个 TRTC将通过一个基于Web的门户来协调所有这些活动，该门户将用于集成所有这些活动 因此，建立了一个单一的入口点，用于获取非政府组织--国家技术合作伙伴机构的核心资源。 为了实现这些目标，我们提出了三个具体目标。在目标1中，我们将建立基础设施 协调进入NNE-CTR核心设施所必需的。一个强大、功能强大的门户网站将是 为实现这一目标迈出有利的一步。在目标2中，实时培训中心将与专业人员合作制定 发展和试点项目计划核心、外联和教育计划，以提高认识， 了解和使用先进的生物医学技术。在AIM 3中，实时控制中心将与跟踪一起工作 以及评价和行政核心，以开发评价工具，以衡量核心设施的使用情况 它们在推进NNE-CTR的临床和翻译研究以及确定 NNE-CTR调查人员未来的基础设施需求。通过增加临床和翻译的能力 通过更好地利用生物医学技术进行调查，将会有新的发现 直接受益的不仅是新英格兰北部农村人口的医疗保健需求，而且是 国家。

PROJECT SUMMARY To address the health issues of the mostly rural northern New England population and build translational research capacity, there is a compelling need to integrate the clinical and translational research infrastructure into a network that brings together the diversity of resources and expertise of Maine Medical Center and the University of Vermont in the Northern New England Clinical and Translational Research Network (NNE-CTR). The goal of the Translational Research Technologies Core (TRTC) of the NNE-CTR is to provide coordinated access to state-of-the-art core facilities developed at the institutions through a combination of COBRE, INBRE, institutional and other forms of support over the last several years. The TRTC will provide access to instrumentation, expertise and other resources crucial to the success of clinical and translational research by NNE-CTR investigators. These resources include infrastructure and technical expertise for genomic, epigenetic, proteomic, cell and tissue analyses and clinical and translational genomics. In addition to providing infrastructure, instrumentation and expertise, the TRTC will provide education and training to investigators about current and emerging technologies that will be essential to the success of their research activities. The TRTC will coordinate all of these activities through a web-based portal that will serve to integrate all of these resources, thus creating a single point of entry for accessing core resources at NNE-CTR partner institutions. To accomplish these goals we propose three specific aims. In Aim 1 we will establish the infrastructure necessary to coordinate access to NNE-CTR core facilities. A robust, highly functional web-portal will be an enabling step towards this goal. In Aim 2, the TRTC will develop, in collaboration with the Professional Development and Pilot Projects Program Cores, outreach and education programs to enhance awareness, understanding and use of advanced biomedical technologies. In Aim 3, the TRTC will work with the Tracking and Evaluation and Administrative Cores to develop evaluation tools to measure the use of core facilities and their effectiveness in advancing clinical and translational research in NNE-CTR as well as to determine the future infrastructure needs of NNE-CTR investigators. By increasing the capacity for clinical and translational investigations through enhanced access to biomedical technologies, new discoveries will be made that will directly benefit not only the health care needs of the rural northern New England population, but that of the nation.