Visible Light Photocatalysis

描述（由申请人提供）：光化学反应对于药物发现是有吸引力的，因为它们能够合成不寻常的、应变的分子框架，这些分子框架不能通过其他方法合成。然而，制药公司很少利用光化学合成，因为需要专门的光化学设备是一个不切实际的障碍，因为很少有方法来控制光化学反应的立体化学存在。因此，通过光化学合成产生的分子的结构基本上没有被检查为可能的候选药物。我们的实验室开创了一种光化学合成的新方法，该方法使用方便、易得的可见光源（例如，家用灯泡，环境阳光），以使光化学合成首次进入药物化学家。该提案有两个平行目标：目标1。光化学反应之立体化学控制策略之发展。目标2.可见光光化学活化新机制之发展。这些方法是强大的，强大的，简单的大规模，工业相关的规模执行。因此，本提案中描述的研究将对学术化学界和更广泛的药物化学家群体产生重大影响，他们需要新的分子构建方法来发现下一代挽救生命的药物。

DESCRIPTION (provided by applicant): Photochemical reactions are attractive for drug discovery because they enable the synthesis of unusual, strained molecular frameworks that cannot be synthesized by other methods. Nevertheless, pharmaceutical companies rarely take advantage of photochemical synthesis because the need for specialized photochemical equipment is an impractical impediment and because very few methods to control the stereochemistry of photochemical reactions exist. Therefore, the structures of the molecules that are produced by photochemical synthesis have essentially not been examined as possible drug candidates. Our laboratory has pioneered a new approach to photochemical synthesis that uses convenient, readily available sources of visible light (e.g., household lightbulbs, ambient sunlight) in order to make photochemical synthesis accessible to medicinal chemists for the first time. This Proposal has two parallel objectives: Aim 1. The development of strategies to control the stereochemistry of photochemical reactions. Aim 2. The development of a novel mechanism of photochemical activation with visible light. These methods are powerful, robust, and simple to perform on large, industrially relevant scales. Thus, the research described in this proposal will significantly impact both the academic chemistry community and the broader community of medicinal chemists who require new methods of molecule construction to discover the next generation of life-saving drugs.