Mentoring in Addiction Treatment Research

项目摘要 K24竞争性更新申请的主要目标是使Eden Evins，M.D.，M.P.H.（1） 开展职业发展活动，以加强和扩大她的以病人为导向的成瘾研究（POAR）; 和2）提供密集和高质量的辅导，以早期职业生涯的调查员在POAR。K24更新将 给Evins博士保护的时间来致力于职业发展，以增加她的临床成瘾的影响 研究和强化指导的初级临床研究人员，否则将花费在临床和 行政职责。Evins博士，哈佛医学院精神病学副教授， 自1999年以来，马萨诸塞州成瘾医学总中心一直在进行POAR，强调研究， 整合不同的治疗方法，接近难以治疗的人群并影响临床实践。 博士Evins已经完成了她最初的K24奖项的主要目标。她已经指导了35多名初级 研究人员，许多与K奖，撰写了100出版物，其中包括42出版物与学员， 第一作者。她进行了一系列研究，改变了吸烟的临床实践指南 为患有严重精神疾病的人提供治疗。 埃文斯博士的研究计划，这一更新申请包括继续工作，作为一个PI在NIDA资助 治疗研究，担任研究的共同研究者，学员作为PI。此外，她计划提交 建议：（1）将为严重精神病患者提供的戒烟治疗范围， 社区，和2）研究大麻使用对精神症状，认知能力和 精神疾病患者和青少年中的成瘾。 Evins博士的指导计划包括在1）药物滥用的临床方面培训她的学员; 2）设计 和实施药物滥用研究; 3）编写科学论文和报告; 4）编写 成功的资助申请;和5）负责任的研究行为。她会用一个 个人和小组会议相结合;协作指导;角色建模;以及整合 与MGH临床研究部和职业发展办公室指导。 Evins博士的职业发展计划包括增加她在多模态和光学方面的专业知识。 神经成像，评估大麻使用对特殊人群的影响;新的数据分析策略;以及 遗传学这些活动将加强Evins博士的研究和指导能力。 这种应用的公共卫生重要性与开发新的有效的 药物依赖和双重诊断患者的治疗，以及培训下一代 研究者需要培养他们所需的技能，以有效地对该患者人群进行POAR。

Project Summary The primary goals of this K24 competing renewal application are to enable Eden Evins, M.D., M.P.H., to 1) conduct career development activities to enhance and extend her patient-oriented addiction research (POAR); and 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will to give Dr. Evins protected time to devote to career development to increase the impact of her clinical addiction research and to intensive mentoring of junior clinical researchers that would otherwise be spent on clinical and administrative duties. Dr. Evins, Associate Professor of Psychiatry at Harvard Medical School and Director of the Mass General Center for Addiction Medicine, has conducted POAR since 1999, emphasizing studies that integrate different treatment approaches, approach difficult to treat populations and influence clinical practice. Dr. Evins has accomplished the major goals of her initial K24 award. She has mentored over 35 junior investigators, many with K awards, has authored 100 publications, including 42 publications with a mentee as first author. She has conducted a series of studies that have changed clinical practice guidelines for smoking cessation for those with serious mental illness. Dr. Evins’ research plan for this renewal application includes continued work as a PI in NIDA funded treatment research, to serve as Co-Investigator on studies with mentees as PI. Further, she plans to submit proposals to 1) expand the scope of smoking cessation treatment for those with serious mental illness to the community, and 2) study effects of cannabis use on psychiatric symptoms, cognitive performance and addiction in those with psychiatric disorders and in adolescents. Dr. Evins’ mentoring plan includes training her mentees in 1) clinical aspects of drug abuse; 2) designing and implementing drug abuse research studies; 3) preparing scientific papers and presentations; 4) writing successful grant applications; and 5) responsible conduct of research. She will accomplish this with a combination of individual and group meetings; collaborative mentoring; role modeling; and integrating mentoring with the MGH Division of Clinical Research and the Office of Career Development. Dr. Evins’ career development plan involves increasing her expertise in multimodal and optical neuroimaging, assessment of effects of cannabis use in special populations; novel data analytic strategies; and genetics. These activities will both enhance Dr. Evins’ research and her mentoring capacity. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.