Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum

项目摘要 脑成像研究揭示了与年龄相关的脑白质、神经化学物质和可能的 精神分裂症谱系障碍患者的皮质改变。然而，成像研究通常是 只专注于大脑，而没有对危险因素进行系统层面的调查。精神分裂症患者的谱系 疾病的寿命也要短得多，发病率和死亡率也很高。然而，医学上的共病 研究通常不包括基于大脑的调查。目前尚不清楚为什么精神分裂症谱系 疾病与年龄相关的医疗负担很高。累积的应激效应预测成功的衰老 健康的老年人。在精神分裂症谱系障碍患者中，累积应激可能会扰乱大脑 结构和功能，和/或受损的大脑结构和功能可能会扭曲对压力的正常反应 导致累积压力效应增加。这项提案研究将研究累积压力和大脑 使用纵向和年龄队列交叉，成像年龄跨度为45岁的年龄进展。 横断面设计。这项研究建议跟踪外围与压力相关的风险因素的进展， 以及大脑中与年龄相关的变化，并确定它们是独立的还是交互的 有助于精神分裂症谱系患者的年龄相关医疗健康和功能结果 精神错乱。这些发现可能会指导临床上可操作的截获异常的策略的发展 在这种毁灭性疾病的患者中，衰老和促进成功的衰老。

Project Summary Brain imaging research has revealed accelerated age-related white matter, neurochemical and perhaps cortical changes in patients with schizophrenia spectrum disorders. However, imaging studies are typically brain-focused without system-level investigations on the risk factors. Patients with schizophrenia spectrum disorders also have a much shorter lifespan and high morbidity and mortality. However, medical comorbidity studies typically do not include brain-based investigations. It remains unclear why schizophrenia spectrum disorders have high age-related medical burden. Cumulative stress effects are predictive of successful aging in healthy older adults. In patients with schizophrenia spectrum disorders, cumulative stress may disrupt brain structure and function, and/or impaired brain structure and function may distort normal responses to stress leading to increased cumulative stress effects. The proposal research will study cumulative stress and brain imaging age-progression in an age span of 45 years, using a combined longitudinal and age-cohort cross- sectional design. The study proposes to track the progression of stress-related risk factors in the periphery, and the age-related changes in the brain, and to determine whether they will independently or interactively contribute to age-related medical health and functional outcomes in patients with schizophrenia spectrum disorders. These findings may guide the development of clinically actionable strategies to intercept abnormal aging and promote successful aging in patients with this devastating illness.