Core F: Research Education Component (RL5)

研究教育组件核心（核心F）-项目摘要 研究教育组成部分（REC）核心将监督制定和实施 针对早期研究者的培训计划，重点是弥合临床前和临床试验之间的差距。 预防、减缓和治疗阿尔茨海默病（AD）的治疗干预的临床开发。我们将 利用丰富的现有机构资源，包括克劳德D.胡椒老年美国人独立 中心，我们的临床和转化科学研究所（CTSI）和维克森林创新（与 提供一个坚实的，多学科的基础设施，以支持多样化的培训课程，重点是 转化AD神经科学研究，特别是关于代谢和 血管危险因素和疾病。我们将从维克森林广泛的科学界中找出 导师，并将招募来自不同种族和民族的早期调查人员和其他受训人员 背景通过多个维克森林中心（例如，ADCC，Sticht老龄化中心，Maya Angelou 健康公平中心，高血压和血管研究中心，比较医学/灵长类动物 中心），并通过附近的附属学术机构，包括两个历史上的黑人学院和 与我们建立合作关系的大学（HBCU）。REC核心将 为初级教师实施一项为期18个月的密集和量身定制的创新培训计划，其中包括新的 转化研究经验和有针对性的指导，以促进从研究孤岛过渡到 高度合作和跨学科的科学。REC还将提供多种其他培训 各级调查员的职业发展机会侧重于从正常 老化到MCI，以及从MCI到AD和其他形式的痴呆使用几个平台（例如，专题讨论会， 研讨会、讲习班、个案会议、期刊俱乐部）。这些和其他REC核心举措将 具体目标如下：1）扩大有前途的初级调查员的职业重点 教师通过一个新的多学科翻译科学映射计划，将提供个性化的 和有针对性的指导，培训和新的研究经验，以支持联合开发 基础科学和临床研究的能力，重点是转化神经科学; 2）支持 研究AD或相关主题的初级研究人员的研究职业发展， 结构化教学培训的多学科课程，这也将侧重于发展战略， 成功的国家学术和工业合作; 3）让来自种族和少数民族的学员参与 在AD研究中严重代表性不足的背景;以及4）评估和改进REC核心 使用学术成功的既定指标的计划。

Research Education Component Core (Core F) – Project Summary The Research Education Component (REC) Core will oversee the development and implementation of training programs for early-stage investigators that will focus on bridging the gap between preclinical and clinical development of therapeutic interventions to prevent, slow, and treat Alzheimer's disease (AD). We will leverage rich existing institutional resources, including the Claude D. Pepper Older Americans Independence Center, our Clinical and Translational Science Institute (CTSI), and Wake Forest Innovations (liaison with industry) to provide a solid, multi-disciplinary infrastructure to support a diverse training curriculum focused on translational AD neuroscience research, particularly with regard to the contributory role of metabolic and vascular risk factors and disease. We will draw from Wake Forest's extensive scientific community to identify mentors, and will recruit early-stage investigators and other trainees from diverse racial and ethnic backgrounds through multiple Wake Forest Centers (e.g., ADCC, Sticht Center on Aging, Maya Angelou Center for Health Equity, Hypertension and Vascular Research Center, Comparative Medicine/Primate Center), and through nearby affiliate academic institutions, including two Historically Black College and Universities (HBCUs) with whom we have established collaborative relationships. The REC Core will implement an innovative 18-month intensive and tailored training program for junior faculty that includes new translational research experiences and targeted mentoring to facilitate transitions from research silos toward highly collaborative and interdisciplinary science. The REC will also provide multiple other training opportunities for investigators at all levels of career development focused on early transitions from normal aging to MCI, and from MCI to AD and other forms of dementia using several platforms (e.g., symposiums, seminars, workshops, case conferences, journal clubs). These and other REC Core initiatives will be addressed with the following Specific Aims: 1) to expand the career focus of promising junior investigators faculty through a new multi-disciplinary Translational Science Mapping Program that will provide individualized and targeted mentoring, training, and new research experiences to support the development of combined competence in basic science and clinical research, with a focus on translational neuroscience; 2) to support research career advancement of junior investigators studying AD or a related topic by providing access to a multi-disciplinary curriculum of structured didactic training, which will also focus on strategies to develop successful national academic and industry collaborations; 3) to engage trainees from racial and ethnic minority backgrounds who are severely underrepresented in AD research; and 4) to evaluate and refine REC Core programs using established metrics of academic success.