Nonhuman Primate Core

NHP核心-项目摘要/摘要 寨卡病毒（ZIKV）在美洲的出现及其与胎儿死亡和出生的关系 缺陷是一个重大的公共卫生挑战。到目前为止，人们对马- 胎儿-胎儿传播的发生以及先天性感染期间影响胎儿病理的因素。 因此，了解妊娠期间ZIKV感染的病理生理学至关重要。的使用 非人灵长类动物（NHP）模型在妊娠期间ZIKV感染将允许精细和快速的检测。 对感染的病理学和持续时间、预先存在的登革热病毒的影响进行检查 感染的免疫力，以及对感染的免疫反应;重要的研究是不可能的， 人类由于猕猴的相对相似性，NHP模型对于这些研究也是理想的 人类怀孕。非人类灵长类（NHP）核心是一个不可分割的组成部分， 该计划的项目，并提供直接支持所有三个项目。NHP核心将提供健康的 动物，协调和实施拟议的NHP实验的各个方面，建立和验证 怀孕和监测产妇和胎儿的健康，进行尸检和详细的组织病理学 检查，评估新生儿的结果，并提供合规监督和生物安全培训， 所有三个项目。

NHP Core - Project Summary/Abstract The emergence of Zika virus (ZIKV) in the Americas and its association with fetal demise and birth defects represents a significant public health challenge. To date, very little is known about how ma- ternal-fetal transmission occurs and what factors influence fetal pathology during congenital infection. Thus, understanding the pathophysiology of ZIKV infection during pregnancy is critical. The use of a nonhuman primate (NHP) model for ZIKV infection during pregnancy will allow finescale and comprehen- sive examination of the pathology and duration of infection, the influence of pre-existing dengue virus immunity on infection, and the immune response to infection; important studies that are not possible in humans. The NHP model is additionally ideal for these studies due to the relative similarity of macaque pregnancies to human pregnancies. The Non-Human Primate (NHP) Core is an integral component of the Program Project and provides direct support to all three Projects. The NHP Core will provide healthy animals, coordinate and implement all aspects of the proposed NHP experiments, establish and verify pregnancies and monitor maternal and fetal health, perform necropsies and detailed histopathological examinations, assess neonatal outcomes, and provide compliance oversight and biosafety training for all three Projects.