TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITY

摘要：抗体应答的持续时间因疫苗或感染的不同而有很大差异。具体的 造成这些差异的免疫原和宿主反应的特点仍然很差 明白了。在本应用中，我们描述了BTB/POZ家族的两个转录因子，它们分别作用于 相反的影响抗体产生的持续时间。其中第一个因子Zbtb20促进血浆 细胞存活和原代长期抗体反应所必需的铝盐，但不是Toll样 受体配体被用作佐剂。第二个因子，Zbtb32，促进浆细胞死亡并限制 记忆B细胞回忆反应后抗体产生的持续时间，但不是一抗 回应。基于这些发现，我们建议建立细胞事件来解释佐剂如何 影响免疫持续时间，揭示抗体多样性的生理后果 回想反应持续的时间太长。此外，我们还建议对分子进行鉴定。 Zbtb20和Zbtb32控制体液免疫持续时间的机制。

Abstract: The duration of antibody responses varies widely with the specific vaccine or infection. The specific features of the immunogen and host responses that are responsible for these differences remain poorly understood. In this application, we describe two transcription factors of the BTB/POZ family which exert opposing effects on the duration of antibody production. The first of these factors, Zbtb20, promotes plasma cell survival and is required for primary long-term antibody responses when aluminum salts, but not Toll-like receptor ligands are used as the adjuvant. The second factor, Zbtb32, promotes plasma cell death and limits the duration of antibody production following memory B cell recall responses, but not primary antibody responses. Based on these findings, we propose to establish the cellular events that explain how adjuvants influence the duration of immunity, and to uncover the physiological consequences to the diversity of antibody responses when recall responses persist for too long. Moreover, we propose to identify the molecular mechanisms of how Zbtb20 and Zbtb32 function to control the duration of humoral immunity.