New Jersey Alliance for Clinical Translational Science: NJ ACTS

联系PD/PI：Panettieri，Alfred亚历山大 项目总结/摘要 概述 协调罗格斯大学生物医学和健康科学（RBHS），新泽西临床和 翻译科学（NJ）由罗格斯大学和普林斯顿大学（PU）组成的联盟，新泽西州 技术研究所（NJIT），医学，护理，牙科和公共卫生学校，医院，社区卫生 中心，门诊实践，行业，决策者和卫生信息交流。所有联盟大学 及其附属机构提供了大量资源，并为规划、发展和领导做出了贡献。 的财团。拥有约700万人口，新泽西州是翻译的“天然实验室”。 和临床研究。新泽西州人口约900万，在美国排名第11位， 人口密度和种族多样性高于平均水平。令人惊讶的是，新泽西州没有CTSA枢纽协调 转化和临床研究。我们的CTSA中心专注于两个首要主题： 疾病的发病机制和对治疗的反应，以及将大型临床数据库与 干预性临床研究，以确定因果关系和预测治疗反应。NJ威尔 提供：采用创新办法，将大型数据库和电子健康记录中的信息联系起来， 临床试验设计、执行和分析;以及使用荧光技术发现生物标志物的新平台， 原位杂交和机器学习来识别慢性疾病的独特神经特征。NJ威尔 访问具有显著成员多样性的大型卫生系统;社区参与的丰富遗产， 以社区为基础的研究平台;和行之有效的方法，以加强劳动力发展的临床 research.在罗格斯大学， 随着新泽西州的成立，存在着一个无与伦比的机会，对数增长的临床 在新泽西做研究为了建立我们作为CTSA中心的参与者和临床互动能力， 成立的试验加速器和招募办公室将协调可行性评估，实施， 招募和临床研究评价。此外，我们将五个临床研究单位组织成一个 凝聚力的网络在战略地点提供非凡的专门知识， 不同的社区，特别关注：儿童;老年人;患有严重精神疾病或 药物滥用问题;由医疗补助服务的低收入个人;艾滋病毒/艾滋病患者;以及所有人 少数群体、服务不足以及健康和环境不平等的受害者。病史包括 合作伙伴和附属机构共享独特的技能、专业知识、培训和指导能力， 在CTSA Hub的基础设施中得到极大的放大。普林斯顿和NJIT，没有医学院或 医院附属机构，寻求与罗格斯大学合作，提供临床研究平台;罗格斯大学寻求PU NJIT在新型信息学平台方面的专业知识，自然语言和本体论方面的专业知识， 认知神经科学新泽西州将共同提供一个联盟，将催化临床研究， 在整个新泽西的培训，以改善人口健康，并有助于CTSA联盟。本修订 在应用方面，总体主题保持不变，但核心的领导和方向已明显改善。 第三百三十七页 项目总结/摘要 联系PD/PI：Panettieri，Alfred亚历山大 新泽西临床和转化科学联盟（NJ）

Contact PD/PI: Panettieri, Reynold Alexander Project Summary/Abstract Overview Coordinated by Rutgers Biomedical and Health Sciences (RBHS), the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) comprises a consortium with Rutgers and Princeton Universities (PU), NJ Institute for Technology (NJIT), medical, nursing, dental and public health schools, hospitals, community health centers, outpatient practices, industry, policymakers and health information exchanges. All Alliance universities and affiliates have provided substantial resources and contributed to the planning, development and leadership of the consortium. With access to ~7 million people, NJ ACTS serves as a ‘natural laboratory’ for translational and clinical research. With a state population of ~9 million, New Jersey ranks 11th in the US, 1st in population density and higher than average in racial and ethnic diversity. Surprisingly, NJ has no CTSA Hub to coordinate translational and clinical research. Our CTSA Hub focuses on two overarching themes: the heterogeneity of disease pathogenesis and response to treatment, and the value of linking large clinical databases with interventional clinical investigations to identify cause-and-effect and predict therapeutic responses. NJ ACTS will provide: innovative approaches to link information from large databases and electronic health records to inform clinical trial design, execution and analysis; and novel platforms for biomarker discovery using fluorescence in situ hybridization and machine learning to identify unique neural signatures of chronic illness. NJ ACTS will access a large health system with significant member diversity; a rich legacy of community engagement and community-based research platforms; and proven approaches to enhance workforce development in clinical research. With a substantial investment in streamlining research administration and IRB practices at Rutgers and with the inception of NJ ACTS, there exists an unparalleled opportunity for logarithmic growth in clinical research in New Jersey. To build our capacity for participant and clinical interactions as a CTSA Hub, the newly established Trial Accelerator and Recruitment Office will coordinate feasibility assessment, implementation, recruitment, and evaluation of clinical studies. Additionally, our organization of five clinical research units into a cohesive network provides extraordinary expertise in strategic locations to enhance participant recruitment from diverse communities with a particular focus on: children; the elderly; those with serious mental illness or substance abuse issues; low-income individuals served by Medicaid; those with HIV/AIDS; and people of all ages who are minorities, underserved, and victims of health and environmental disparities. With a history of collaboration, partners and affiliates share unique skills, expertise, training and mentoring capabilities that will be greatly amplified within the infrastructure of a CTSA Hub. Princeton and NJIT, without medical schools or hospital affiliates, seeks collaboration with Rutgers to provide clinical research platforms; Rutgers seeks the PU and NJIT expertise in novel informatics platforms, expertise in natural language and ontology, machine learning and cognitive neurosciences. Together NJ ACTS will provide an alliance that will catalyze clinical research and training across New Jersey to improve population health and contribute to the CTSA Consortium. In this revised application, the overall themes remain unchanged but Cores leadership and direction has been markedly refined. Page 337 Project Summary/Abstract Contact PD/PI: Panettieri, Reynold Alexander New Jersey Alliance for Clinical and Translational Science (NJ ACTS)