Intersection of Physiologic Frailty and Cognitive Performance in Older Adults: An Integrative Data Analysis

 描述(由申请人提供)：奥尔登·L·格罗斯是约翰霍普金斯大学布隆伯格公共卫生学院流行病学系的助理教授。他寻求获得有指导的职业发展奖，以获得衰老生物学方面的关键知识技能，特别是与老年人虚弱有关的知识技能，以及必要的研究经验 作为老年流行病学家的独立职业。培训申请详细说明了关于脆弱和衰老生理基础的正式和非正式指导的五年计划，其中包括由现有专家团队进行的指导研究、课程作业、研讨会、由导师指导的脆弱研究、在丰富的教育工作组中的合作、国家和地方会议，以及根据培训情况进行的指导研究。短期职业目标包括完成衰老生物学和实践方面的课程，通过出版物和演示文稿传播高质量的指导研究，从事职业发展活动，并从获奖期的第四年开始申请独立的R01资金。长期的职业目标是成为一名独立的精神病学流行病学家，在衰老生物学方面拥有丰富的专业知识，特别是在与老年人虚弱有关的生物学方面。这项研究的具体目的是开发和验证一种客观的方法，在对三个纵向数据集的综合数据分析中，使用跨多个身体系统的调节失调的生理标记物的组合来衡量生理脆弱，确定生理脆弱或认知障碍是否预测其他系统随后的变化，并评估生理脆弱变化和认知下降之间的相互关系，并关注对未来公共卫生干预的影响。建议进行一项辅助研究，以丰富现有的生物标志物数据。拟议目标的完成将提供初步结果，为加强干预奠定基础，以确立脆弱作为干预或筛查随后认知能力下降的机会的窗口。

 DESCRIPTION (provided by applicant): Alden L. Gross is an Assistant Professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. He seeks a mentored career development award to obtain critical knowledge skills in the biology of aging, particularly as it relates to frailty in older adults, and necessary research experience for an independent career as an epidemiologist in aging. The training application details a five year plan of formal and informal instruction in the physiological basis of frailty and aging consisting f mentored research by an established team of experts, coursework, seminars, guided study in frailty by mentors, collaborations in richly educational working groups, national and local meetings, and mentored research informed by the training. Short-term career goals include to complete coursework in the biology of aging and practice, disseminate high-quality mentored research through publications and presentations, engage in career development activities, and apply for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent psychiatric epidemiologist with content expertise in the biology of aging, particularly as it relates to frailty in older adults. The specific aims of the research proposed are to develop and validate an objective method for measuring physiological frailty using combinations of physiological markers of dysregulation across multiple body systems in an integrative data analysis of three longitudinal datasets, to determine whether physiological frailty or cognitive impairment predicts subsequent change in the other, and to evaluate reciprocal relationship between changes in physiological frailty and cognitive decline with attention to implications for future public health interventions. An ancillary study is proposd to enrich existing biomarker data. Completion of the proposed aims will provide preliminary findings that will lay the groundwork for mounting interventions to establish frailty as a window o opportunity for intervention or screening of subsequent cognitive decline.