Biomedical Informatics Core

项目摘要：生物医学信息学(BMI)核心 路易斯安那州临床和医学中心生物医学信息学(BMI)关键组件活动(KCA)的使命 翻译科学中心(LA CATS)将开发和部署最先进的生物医学信息学 所有合作机构的能力和服务，以支持旨在 改善健康结果和解决我们最脆弱人群中的差距。在过去4年中 多年来，BMI KCA支持了14个机构的55名洛杉矶CATS调查人员，出版了27份出版物和 7项资助拨款申请。在下一个资金期，BMI KCA将追求几个创新目标： 1)为对路易斯安那州患者造成不成比例影响的疾病创建可搜索的i2b2“虚拟队列”； 2)参与东南神社和TriNetX临床数据网络；3)基因组整合， 病理和临床数据集；以及4)创建可搜索的“虚拟生物储存库”，将物理 洛杉矶猫科动物机构的生物信息库。我们将利用与以下方面的关键合作：PCORI资助 UAB和南卡罗来纳医科大学(MUSC)领导的CTSA中心；精密医学 和新奥尔良LSUHSC的生物信息学项目，以及路易斯安那州肿瘤登记处(LTR)。我们是 很高兴将我们的服务扩展到我们洛杉矶CATS的新合作机构：LSUHSC牙科和 护理学校、路易斯安那东南部退伍军人医疗系统、纽约大学医学中心 奥尔良和奥克斯纳健康系统。为了完成我们的使命，我们提出了以下目标： 具体目标1.显著扩展正在进行的BMI服务，并在我们的经验基础上开发新的 用于数据挖掘、精确医学和分子流行病学的分析工具。 具体目标2.扩大我们的能力，使洛杉矶猫之间能够进行有意义的协作和数据共享 研究人员和路易斯安那州的路易斯安那州生物医学研究网络(LBRN)和生物医学中心 卓越研究(Cobre)中心，以及洛杉矶CATS研究人员和CTSA中心之间的区域合作 以及在全国范围内，并增加对服务不足人群的网络访问。 具体目标3.为项目设计和实施提供持续、协调的支助 专业发展，与临床研究资源(CRR)、设计、 流行病学和生物统计学(DEB)、网络基础设施增强(CE)、专业发展 (PD)、道德和监管知识(ERKC)和健康素养(HL)KCA。

PROJECT SUMMARY: BIOMEDICAL INFORMATICS (BMI) CORE The mission of the Biomedical Informatics (BMI) Key Component Activity (KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to develop and deploy “state of the art” biomedical informatics capabilities and services across all partner institutions, in support of clinical and translational research aimed at improving health outcomes and addressing disparities in our most vulnerable populations. Over the past 4 years, the BMI KCA supported 55 LA CaTS Investigators across 14 institutions, resulting in 27 publications and 7 funded grant applications. During the next funding period, the BMI KCA will pursue several innovative goals: 1) the creation of i2b2-searchable “virtual cohorts” for diseases disproportionately affecting Louisiana patients; 2) the participation in the Southeast SHRINE and TriNetX clinical data networks; 3) the integration of genomic, pathologic and clinical datasets; and 4) the creation of a searchable “virtual biorepository” linking physical biorepositories across LA CaTS institutions. We will leverage key collaborations with: PCORI-funded REACHnet; UAB- and Medical University of South Carolina (MUSC)-led CTSA Centers; the Precision Medicine and Bioinformatics Programs at LSUHSC-New Orleans, and the Louisiana Tumor Registry (LTR). We are excited about expanding our services to our LA CaTS new partner institutions: the LSUHSC Dental and Nursing Schools, the Southeast Louisiana Veterans Healthcare System, the University Medical Center in New Orleans and Ochsner Health System. To accomplish our mission, we propose the following aims: Specific Aim 1. To significantly expand ongoing BMI services and to build on our experience to develop novel analytical tools for data mining, precision medicine and molecular epidemiology. Specific Aim 2. To expand our ability to enable meaningful collaboration and data sharing between LA CaTS Investigators and Louisiana-based Louisiana Biomedical Research Network (LBRN) and Centers of Biomedical Research Excellence (COBRE) Centers, and between LA CaTS Investigators and CTSA Centers regionally and nationally, and to increase cyber access to underserved populations. Specific Aim 3. To provide continued, coordinated support for project design and implementation and professional development, in close cooperation with the Clinical Research Resources (CRR), Design, Epidemiology and Biostatistics (DEB), Cyberinfrastructure Enhancement (CE), Professional Development (PD), Ethics and Regulatory Knowledge (ERKC) and Health Literacy (HL) KCAs.