Bone and Muscle Interaction: the Mechanical and Beyond

摘要 与骨骼、关节和肌肉有关的肌肉骨骼系统的疾病、紊乱和损伤是 美国残疾和医疗费用的主要原因(国内生产总值的5.7%)。预计全球将有20%的人口 到2050年，人口将达到60岁及以上，到2150年将超过35%，残疾和由此产生的医疗保健费用只会 增加。越来越明显的是，肌肉和骨骼通过生物化学和分子相互作用 相声不仅仅是肌肉对骨骼的加载。一种组织的疾病可能使另一种组织更容易患病。 例如，骨质疏松症是先于骨质疏松症，还是与骨质疏松症同时发生，或者是骨质疏松症的结果，目前尚不清楚。一个 开创性的会议于2012年在堪萨斯城举行，由美国骨骼和矿物协会主办 这项研究将研究人员聚集在一起，解决了这样一个问题：肌肉和肌肉之间是否存在相互作用 机械之外的骨头？“当时，骨场和肌场主要是竖井状的，很少 互动。从那时起，一个新的研究领域--骨骼和肌肉相互作用--已经建立起来。它是 现在是进行后续会议的时候了，该会议提出这样一个问题：“肌肉和骨骼相互作用的证据是什么？” 除了机械性之外，这些新的信息如何导致肌肉骨骼的潜在治疗 疾病？“印第安纳肌肉骨骼健康中心(ICMH)计划主办一场名为“骨骼和肌肉”的会议 2019年8月，《互动：机械与超越》来解决这一问题。这样做的具体目的是 会议的目的是：1)汇聚骨、肌肉和骨肌肉领域的国内和国际领先者 互动，以启动和促进肌肉-骨骼互动新领域的合作研究；2)刺激 通过促进集思广益会议、小组讨论、小组讨论、创新比赛- 匹配活动，以及计划的、有目的的一对一互动；3)确定宣传、通知和 支持骨骼-肌肉相互作用的新领域；以及4)传播关于新领域的信息，如 作为最新的想法、合作的潜力以及资金和支持的新机会。一份总结报告 会议纪要将提交出版。会议将集中在衰老过程中的骨骼-肌肉相互作用， 癌症、能量和新陈代谢、骨科、营养学、儿童和成人遗传和肌肉骨骼 疾病，以及肌肉-骨骼相互作用的可溶性因子和运动释放的介体。的最终目标是 这次会议将引发预防和治疗肌肉骨骼疾病的新战略。

ABSTRACT Diseases, disorders, and injuries of the musculoskeletal system relating to bones, joints, and muscles are the leading cause of disability and health care costs in the U.S. (5.7% GDP). With a projected 20% of the world population being 60 and older by 2050 and over 35% by 2150, disability and resulting health care costs will only increase. It is becoming increasingly evident that muscle and bone interact through biochemical and molecular crosstalk beyond just the loading of bone by muscle. Diseases of one tissue may predispose the other to disease. For example, it is not known if osteoporosis precedes, occurs concurrently with or is the result of sarcopenia. A seminal meeting took place in Kansas City in 2012 sponsored by the American Society for Bone and Mineral Research that brought investigators together to address the question “Is there interaction between muscle and bone beyond the mechanical?” At that time, the bone field and the muscle field were mainly siloed with little interaction. Since then a new field of research, that of bone and muscle interactions, has been established. It is now time for a follow-up meeting that asks the question, “What is the evidence that muscle and bone interact beyond the mechanical and how can this new information lead to potential treatments for musculoskeletal disease?” The Indiana Center for Musculoskeletal Health (ICMH) plans to host a meeting “Bone and Muscle Interactions: The Mechanical and Beyond” in August 2019 to address this question. The specific aims of this meeting are to: 1) Bring together national and international leaders in bone, muscle, and bone-muscle interactions to initiate and promote collaborative studies in the new field of muscle-bone interactions; 2) Stimulate new ideas through facilitated brainstorming sessions, group discussions, panel discussions, innovative match- matching events, and scheduled, intentional one-on-one interactions; 3) Identify means to promote, inform, and support the new field of bone-muscle interactions, and; 4) Disseminate information regarding the new field, such as the latest ideas, potential for collaboration, and new opportunities for funding and support. A summary report of the meeting will be submitted for publication. Sessions will center on bone-muscle interactions in aging, cancer, energetics and metabolism, orthopaedics, nutrition, pediatric and adult genetic and musculoskeletal disease, and soluble factors and exercise-released mediators of muscle-bone interactions. The ultimate goal of this meeting is to trigger new strategies for preventing and treating musculoskeletal disease.