DELINEATING THE ROLE OF GENETIC INFLUENCES ON CANNABIS INVOLVEMENT

此次竞争续签独立调查员职业发展奖(K02)旨在扩大 候选人在大麻遗传研究方面的研究专长涉及两个主要领域：(A)整合 神经成像和新出现的涉及大麻的基因组结果；和(B)基因组的新方法 (元)分析，特别是了解基因组因素如何影响大麻之间的共病 参与与精神和心理社会相关。她还将与世界各国领导人密切合作 大数据精神遗传学领域扩展她在管理财团、开发小说方面的专业知识 合作，将她的工作扩展到临床方向，并在传播和社区参与方面。在……里面 此外，候选人将继续指导学员上瘾和基因组方法，并保持她 负责任地进行研究方面的培训。此K02的首要目标是为候选人提供一个 终身副教授，有保护的时间进行研究，分析遗传影响的作用 与大麻有关。这项研究的公共卫生意义尤其适时，因为 围绕娱乐用大麻地位的立法变化席卷了全国，并引起了科学上的兴趣 大麻使用的有害关联和后果加剧。候选人的研究档案是 在为数不多的主要专注于对大麻参与的遗传知情研究和 继续用实证研究结果指导这场研究辩论。在第一阶段资金的支持下， 候选人发表了许多同行评议的研究，并产生了记录(A)新的基因座的研究结果 大麻使用障碍(CUD)，(B)儿童期虐待对CUD遗传风险的作用和(C)多基因 CUD变异的遗传解剖方法。她还更新了现有的R01并确保 为另外两架R01提供资金。最近，她与他人共同创立了精神病学基因组学联盟 物质使用障碍(PGC-SUD)工作组，高功率PGC曲目的新成员 全基因组关联荟萃分析研究。下一阶段的培训和协作将扩展 候选人在一个现有的(基因组学)和一个新的(神经遗传学)方向的专业知识。第一，通过参与 在PGC中，候选人将掌握最新开发的基因组方法，包括整合 生物信息学和表观基因组注释的方法。这将巩固她在现代基因组学中的知识 方法，并允许她将PGC-SUD组发展为高质量SUD遗传学的首要来源 研究。其次，应聘者将精通神经成像和成像遗传学方法 开始将她的基因组发现与神经生物学的相关性结合起来。这将有效地定位 提出前沿成像遗传学研究应用的候选人。总体而言，继续提供资金将 产生高质量的同行评议的出版物，这将有助于关于病因学的公共辩论， 大麻是一种非常受欢迎的精神活性物质，其使用的进展和后果。

This competing renewal of an Independent Investigator Career Development Award (K02) aims to expand the candidate's research expertise in genetic studies of cannabis involvement in two main areas: (a) integration of neuroimaging with emerging genomic results for cannabis involvement; and (b) new methodology for genomic (meta) analyses, in particular, understanding how genomic factors influence the comorbidity between cannabis involvement and psychiatric as well as psychosocial correlates. She will also work closely with leaders in the field of big data psychiatric genetics to expand her expertise in managing consortia, developing novel collaborations, expanding her work in a clinical direction and in dissemination and community engagement. In addition, the candidate will continue to mentor trainees in addiction and genomic methods and maintain her training in responsible conduct of research. The overarching goal of this K02 is to provide the candidate, a tenured Associate Professor, with protected time to conduct research on parsing the role of genetic influences on cannabis involvement. The public health significance of this research is particularly timely as a wave of legislative change surrounding the status of recreational cannabis sweeps the nation and scientific interest in the deleterious correlates and consequences of cannabis use intensifies. The candidate's research portfolio is amongst the few that is primarily focused on genetically informed studies of cannabis involvement and continues to inform this research debate with empirical findings. With support from the first phase of funding, the candidate published numerous peer-reviewed studies, and generated findings documenting (a) new loci for cannabis use disorders (CUD), (b) the role of childhood abuse on genetic risk for CUD and (c) polygenic approaches to genetic dissection of variance in CUD. She has also renewed her existing R01 and secured funding for two additional R01s. Most recently, she co-established the Psychiatric Genomics Consortium's Substance Use Disorders (PGC-SUD) workgroup, a new addition to the PGC repertoire of highly powered genomewide association meta-analytic studies. The next phase of training and collaboration will extend the candidate's expertise in one existing (genomics) and one novel (neurogenetics) direction. First, via involvement in the PGC, the candidate will master the most recently developed genomic methods, including integrated approaches for bioinformatics and epigenome annotation. This will solidify her knowledge in modern genomic methods and allow her to develop the PGC-SUD group as the foremost source for high quality SUD genetics research. Second, the candidate will gain proficiency in neuroimaging and imaging genetics approaches to begin to integrate her genomic discoveries with neurobiological correlates. This will effectively position the candidate to propose cutting-edge imaging genetics research applications. Overall, continued funding will result in high-quality, peer-reviewed publications that will contribute to the public debate regarding the etiology, progression and consequences of the use of cannabis, a highly popular psychoactive substance.