Developmental Research Program

发展研究方案摘要/摘要 发展研究计划(DRP)的目的是资助研究人员有前途的项目 他目前的工作可能并不完全集中在子宫内膜癌上，但他们提出了高度创新的建议 子宫内膜癌的翻译研究可能成为全孢子项目或竞争成功 在孢子机制之外提供资金。DRP提供了一个独特的场所，使重要的 财政支持，并通过一个迅速发展的方案展示积极的机构支持 对新的想法或倡议作出反应。此外，该计划植根于 孢子调查员，他们有从其他学科带来调查人员的广泛记录 进入子宫内膜癌研究领域。发展研究计划的优势在于其 有能力提供财务支持，并获得整个 孢子，包括孢子芯。这将使我们能够开发重要的协作、多调查人员、多 机构研究项目，由研究人员发起的创新项目支持，这些项目具有 有潜力蓬勃发展为孢子的可靠和富有成效的翻译研究项目。预建议书 本计划将以1页意向书的形式征求申请者的意向书，申请者应预先提交 对于这一计划的目标具有很强竞争力的人将被邀请提交一份完整的提案供审查。《DRP》 主任将帮助调查人员提交建议，以制定相关的翻译研究目标和 计划，因为许多申请者可能在这类研究方面没有先前的专业知识。因此，这一进程将是 一项主要的教育活动，预计将进一步刺激子宫内膜癌的翻译研究 并鼓励基础科学研究人员和临床研究人员参与翻译 研究。DRP将由托马斯·伯克医学博士领导，他是子宫内膜癌孢子的创立者PI和 现任MD Anderson癌症网络副总裁，张伟博士， 病理学系，具有癌症生物学、基因组学和miRNA构建方面的专门知识 信令网络。拉塞尔·布罗德杜斯，医学博士，孢子公司，将为DRP提供监督。这个 DRP对于孢子的持续成功至关重要，现在参与其中的四名前DRP奖获得者证明了这一点 作为研究项目，Co-Pis在这一应用中，第五是孢子项目的重要合作研究员。 另外两名前DRP获奖者将通过在外部咨询服务来提供他们的科学专业知识 冲浪板。

Developmental Research Program SUMMARY/ ABSTRACT The purpose of the Developmental Research Program (DRP) is to fund promising projects by investigators whose current work may not focus exclusively on endometrial cancer, but who propose highly innovative translational studies of endometrial cancer that could become full SPORE projects or compete successfully for funding outside of the SPORE mechanism. The DRP provides a unique venue for making available significant financial support, and for demonstrating active institutional support, through a program that is rapidly responsive to new ideas or initiatives. Moreover, this program is rooted in a spirit of collaboration espoused by the SPORE investigators, who have an extensive track-record of bringing investigators from other disciplines into the field of endometrial cancer research. The strength of the Developmental Research Program rests in its ability to make available financial support and access all the critical expertise and resources within the entire SPORE, including SPORE Cores. This will allow us to develop important collaborative, multi-investigator, multi- institutional research projects with the support of innovative, investigator-initiated projects that have the potential to flourish into reliable and productive translational research projects for the SPORE. Pre-proposals in the form of 1 page letters of intent will be solicited by the Program, and applicants with pre-proposals that are highly competitive for the goals of this program will be invited to submit a full proposal for review. The DRP Directors will help investigators submitting proposals to formulate relevant translational research aims and plans, as many applicants may not have prior expertise in this type of research. This process will therefore be a major educational activity that is further anticipated to stimulate translational research in endometrial cancer and encourage the participation of both basic science researchers and clinical investigators in translational research. The DRP will be led by Thomas Burke, M.D., the founding Endometrial Cancer SPORE PI and current Vice President of the MD Anderson Cancer Network, and Wei Zhang, Ph.D., a Professor in the Department of Pathology with specific expertise in cancer biology, genomics, and construction of miRNA signaling networks. Russell Broaddus, M.D., Ph.D., SPORE Co-PI, will provide oversight to the DRP. The DRP is critical to the continued success of the SPORE, as shown by four former DRP awardees now involved as research project Co-PIs in this application, and a fifth is an important co-investigator on a SPORE project. Two other former DRP awardees will provide their scientific expertise by serving on the External Advisory Board.