2/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research

马萨诸塞州大学波士顿分校和丹娜-法伯/哈佛癌症研究所 中心（DF/HCC）于2002年8月启动了他们的伙伴关系。2000年期间伙伴关系的最初几年 U 56资助期（2005-2010年）建立了所需的基础支持和科学领导， 建立一个坚实和充满活力的研究合作。展望未来，U 54机制借鉴了这一点， 基金会在研究、能力建设和外联方面开展了一系列强有力的活动。两个关键 马萨诸塞大学波士顿分校和DF/HCC之间的持续合作伙伴关系遵循以下原则：a）共同而紧密的 关注解决癌症发病率中的种族、民族和社会经济差异问题， 发病率和死亡率;以及B）相信通过伙伴关系，每个机构都将获得收益 这两个国家都无法独自实现。本申请提供了大量证据， 这些原则的运作方式，对两个机构产生的好处以及 这一伙伴关系现在准备在更高的水平上取得重大进展， 癌症控制我们提出的活动利用最新的科学来理解和解决 通过跨学科的方法，体现了我们的伙伴关系的主题“细胞， 社会为了支持我们新的凝聚力主题，我们提出了三个复杂的，高度竞争的 跨几个基础生物医学和人口科学领域的研究项目，将采用 证据和方法，以汇集和影响癌症和癌症健康差异在多个 分析水平。为了阐明研究机会的新领域，伙伴关系很高兴探索 生物科学与社会/行为科学之间的交叉。当务之急 总结： ” 该伙伴关系的主要内容是：1）继续在马萨诸塞大学进行生物医学和癌症研究的能力建设 DF/HCC的波士顿和癌症差异研究; 2）加强和扩大研究经验， 特别关注代表性不足的少数民族（URM）的学生，在整个教育 管道-从本科到博士后水平（见研究教育核心）; 3）继续关闭 指导早期研究人员，重点是研究和职业发展; 4）建立一个 强大而有力的外联核心，从传播和 实施科学（D&I），以建立伙伴关系、转化知识和监测成果 在社区组织中建立和维持能力的翻译工作（见 5）通过两个服务核心向U 54调查人员提供基础设施支持， 包括研究设计和分析，以及基因组学核心（见共享资源核心）;以及6） 通过专门的规划和管理，确保项目、核心和研究教育计划的可持续性， 执行与NIH机制、基金会支持和/或机构支持的赠款匹配。

The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) initiated their Partnership in August 2002. The early years of the Partnership during the U56 funding period (2005-2010) established the foundational support and scientific leadership needed to build a solid and vibrant research collaboration. Moving forward, the U54 mechanism drew on this foundation resulting in a robust set of activities in research, capacity building and outreach. Two key tenets guide this sustained partnership between UMass Boston and DF/HCC: a) A common and intense interest in addressing the problem of racial, ethnic, and socioeconomic disparities in cancer incidence, morbidity, and mortality; and b) A belief that through the Partnership, each institution will achieve benefits that neither could achieve on its own. This application for renewal provides extensive evidence of the ways these tenets have been operationalized, the resulting benefits for both institutions and the ways in which this Partnership is now poised to make, at an elevated level, significant advances to the science of cancer control. We are proposing activities that draw on the latest science to understand and address cancer disparities through a transdisciplinary approach that embodies our Partnership theme of “Cells to Society. In support of our new cohesive theme, we have proposed three sophisticated, highly competitive research projects across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. To elucidate new areas of research opportunity, the Partnership is excited to explore the intersection between biology-based sciences and social/behavioral sciences. The immediate priorities Summary: ” of the Partnership are: 1) Continuing capacity building for biomedical and cancer research at UMass Boston and cancer disparities research at DF/HCC; 2) Enhancing and scaling up research experiences for students with a specific focus on underrepresented minorities (URMs), across the entire educational pipeline –from undergraduate to postdoctoral levels (see Research Education Core); 3) Continuing close mentoring of early stage investigators with a focus on research and career development; 4) Building a strong and robust Outreach Core that draws on the state of the science from dissemination and implementation sciences (D&I) for building partnerships, translating knowledge and monitoring the results of the translation efforts to build and sustain capacity among community-based organizations (see Outreach Core); 5) Offering infrastructural support to U54 investigators through two service cores, including the Research Design and Analysis, and Genomics Cores (see Shared Resource Core); and 6) Ensuring sustainability for projects, Cores and research education programs via dedicated planning and execution of grant matching with NIH-mechanisms, foundation support and/or institutional support.