Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

项目摘要/摘要 发声功能亢进(VH)与最常见的发音障碍类型有关。这些 包括良性声带病变(如小结和息肉)和发音困难。 并发病理(例如，肌肉紧张性发音困难)。有效的预防和临床处理 由于对病因和病理生理学机制的了解有限，疾病继续受到阻碍。 在与VH相关的广泛范围内，这是特定的语音障碍的基础。为了满足这一需求， 这个临床研究中心汇集了一支由经验丰富的研究人员组成的多学科团队，以追求 全面的研究计划侧重于功能亢进性嗓音障碍。这次会议的中心主题是 中心认为，通过以下方法可以显著改善功能性发声障碍的临床管理 更好地了解这些疾病的病因和病理生理学，然后翻译 将这些知识转化为新的、更有效的预防、诊断和治疗方法。 这项工作的一个中心前提是，多种因素以不同的方式贡献和相互作用，导致和 维持与VH有关的各种障碍，最重要的是与行为有关， 感觉运动、环境、心理/情绪、生理和生物力学机制。这个 跨学科研究计划将重点放在全面了解 这些因素与VH的不同表现之间的关系。该中心的研究将是 由一个新的全面的VH理论框架指导和协调，该框架清楚地说明了 假说将由三大研究项目和科学研究项目共同评估 组成中心的核心。该中心的项目将采用创新的实验室组合 感觉运动和生理机制的研究；语音运动控制的神经网络建模； 发声机制的计算和物理模拟；以及移动生物传感器的使用 探讨日常发声、心理应激和心理应激对发声功能的影响 VH患者和正常对照组的环境声级。使用非卧床服务 还将评估作为治疗策略的生物反馈。该中心的一个重要优势将是 通过科学核心对所有参与者进行集中征聘和临床管理，这将 极大地促进了项目成果的整合，并扩大了中心的影响 各部分的总和。 这个研究多动症发声障碍的项目在其范围、集成度方面都是前所未有的 跨多个领域的信息，许多创新的概念和方法正在 同时开发和测试，以及它显著改善临床管理的潜力 这些障碍。实现这一研究计划的目标将导致改善预防、差别 诊断，以及对这些非常流行的疾病进行更有针对性和更有效的治疗。

Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders continue to be hampered by limited knowledge of the etiological and pathophysiological mechanisms that underlie specific voice disorders within the broad range of those associated with VH. To address this need, this Clinical Research Center brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The central theme of the Center is that the clinical management of hyperfunctional voice disorders can be significantly improved by attaining a better understanding of the etiology and pathophysiology of these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis, and treatment. A central premise of this work is that multiple factors contribute and interact in different ways to cause and maintain the various disorders linked to VH, with the most important being associated with behavioral, sensorimotor, environmental, psychological/emotional, physiological, and biomechanical mechanisms. The interdisciplinary research program will focus on attaining a comprehensive understanding of the fundamental relationships between these factors and the different manifestations of VH. Research at the Center will be guided and coordinated by a new comprehensive theoretical framework for VH that clearly illustrates the key hypotheses that will be assessed in a combined effort by the three major Research Projects and Scientific Core that comprise the Center. The Center’s Projects will employ an innovative combination of laboratory studies of sensorimotor and physiologic mechanisms; neural network modeling of voice motor control; computational and physical modeling of phonatory mechanisms; and the use of ambulatory biosensors to investigate the potential differential impact on vocal function of daily voice use, psychological stress, and environmental sound level in patients with VH and well-matched normal controls. Use of ambulatory biofeedback as a treatment strategy will also be assessed. A significant strength of the Center will be the centralized recruitment and clinical management of all participants through the Scientific Core, which will greatly facilitate the integration of results across the projects and magnify the impact of the Center well beyond the sum of its parts. This program of research in hyperfunctional voice disorders is unprecedented in terms of its scope, integration of information across multiple domains, number of innovative concepts and methods that are being simultaneously developed and tested, and its potential to significantly improve the clinical management of these disorders. Achieving the goals of this research program will lead to improved prevention, differential diagnosis, and more focused and efficient treatment of these very prevalent conditions.