Clinical Research Core (RC 1)

项目总结 临床研究核心(RC1)是佛罗里达大学(UF)老年美国人成功的关键 独立中心(OAIC)。临床研究中心提供进行临床研究的资源和专业知识。 跨越临床试验的调查范围以及风险和结果的观察性研究 与行动不便和预防残疾有关。它的主要目标是鼓励和促进临床 这一领域的翻译研究。 RC1有三个具体目标： 目标1：提供资源和智力环境，促进临床研究、团队科学和 伊斯兰会议组织青年学者与行动能力和预防残疾有关的教育。 目的2：促进和便利将临床前和试点研究转化为老年人的临床试验。 目标3：提高我们对可能影响反应的行为、认知和生理因素的理解 旨在改善老年人行动能力和预防残疾的干预措施。 RC1充当所有OAIC核心的专业知识、数据和产品汇聚到的中央枢纽 产生从试验/探索和开发项目到更大的第二阶段、第三阶段、 以及与行动能力和残疾预防有关的IV疗效和有效性试验。RC1提供 资源和人员(包括U01和R01资助的调查人员)，以支持开发和 实施临床试验。这些措施包括药理、营养和行为干预，以及 老年人活动障碍的原因及其对功能的影响的观察性研究 衰弱和残疾。在与其他OAIC核心密切合作的基础上，RC1将支持 试点/探索性项目、发展项目和外部项目。此外，高级调查人员 将作为职业发展导师领导这些项目，提供 专业知识，并促进初级教员研究以及高级教员协作的丰富环境。

PROJECT SUMMARY The Clinical Research Core (RC1) is key to the success of the University of Florida (UF) Older Americans Independence Center (OAIC). The RC1 provides the resources and expertise for conducting clinical research across the spectrum of investigation of clinical trials as well as observational studies of risk and outcomes related to mobility and the prevention of disability. Its primary goal is to encourage and facilitate clinical translational research in this area. The RC1 has three Specific Aims: Aim 1: Provide the resources and intellectual environment to facilitate clinical research, team science, and OAIC Junior Scholars' education related to mobility and the prevention of disability. Aim 2: Promote and facilitate the translation of preclinical and pilot studies into clinical trials in older persons. Aim 3: Improve our understanding of behavioral, cognitive, and physiological factors that may affect responses to interventions designed to improve mobility and prevent disability in older adults. The RC1 functions as the central hub to which the expertise, data and products of all OAIC cores converge to produce research projects ranging from pilot/ exploratory and developmental projects, to larger Phase II, III, and IV efficacy and effectiveness trials related to mobility and prevention of disability.The RC1 provides resources and personnel (including U01- and R01-funded investigators) to support the development and implementation of clinical trials. These include pharmacologic, nutritional, and behavioral interventions, and observational studies of the causes of mobility impairment in older adults and the implications for functional decline and disability. Building on close collaborations with other OAIC cores, the RC1 will support pilot/exploratory projects, developmental projects, and external projects. In addition, senior-level investigators with established track record will serve as career-development mentors to lead these projects, provide expertise, and promote a rich environment for junior-faculty research as well as senior-faculty collaboration.