The role of the intracellular complement system - the complosome - in monocytes

我们最近(2017年2月)将实验室从伦敦迁至美国国立卫生研究院。在这里工作期间，我们获得了定义人类T细胞和单核细胞内C5激活途径的数据，并表明这种细胞内C5激活对T细胞/单核细胞产生IL-1b至关重要。我们目前正在使用适当的CVD小鼠模型来评估这一观察的体内生物学意义。我们还在体外测试细胞渗透性C5抑制剂的效果，着眼于临床前模型的发展。

We have recently (February 2017) moved laboratories from London to the NIH. While working here, we have obtained data defining the pathways by which intracellular C5 is activated in human T cells and monocytes and have shown that this intracellular C5 activation is critical to IL-1b production by T cells/monocytes. We are currently assessing the in vivo biological significance of this observation using appropriate CVD mouse models. We are also testing the effects of cell-permeable C5 inhibitors in vitro with an eye on the development of preclinical models.