Administrative Core

行政核心总结 太平洋西北先进化合物鉴定核心(PNACIC)的组织是为了支持 新的、改变范式的代谢组学方法学将极大地扩大与生物医学相关的 在代谢组学研究中可以快速和准确地鉴定的化合物，并传播这些进展 给代谢组学社区，使其能够在常规研究中随时和广泛地采用。我们的行政核心意志 促进计算和实验组件与工作人员之间的交互和沟通 PNACIC，对预算和研究活动提供负责任的财政监督，包括数据生成、质量控制 以及保证、旅行和协作；将确保及时共享数据和传播研究产品 PNACIC的成果；并将促进PNACIC与NIH共同基金代谢组学的互动 计划联盟。这项工作意义重大，因为它管理PNACIC的活动和资源，并实现 其计算核心和实验核心之间的强大凝聚力，为代谢组学提供了领先地位 财团。这项工作具有创新性，因为它将利用PNNL的现有基础设施和机制立即 与科学界合作并向科学界传播PNACIC资源。

ADMINISTRATIVE CORE SUMMARY The Pacific Northwest Advanced Compound Identification Core (PNACIC) is organized to support the development of a new, paradigm-shifting metabolomics methodology that will greatly expand the number of biomedically relevant compounds that can be quickly and accurately identified in metabolomics studies, and to disseminate these developments to the metabolomics community, enabling their ready and broad adoption in routine studies. Our Administrative Core will facilitate the cross-interaction and communication between the computational and experimental components and staff of the PNACIC, provide responsible fiscal oversight of budget and research activities, including data production, quality control and assurance, travel, and collaborations; will ensure timely data sharing and dissemination of research products are central outcomes of the PNACIC; and will promote interactions of the PNACIC with the NIH Common Fund Metabolomics Program Consortium. This work is significant because it manages the activities and resources of the PNACIC and achieves strong cohesion between its Computational and Experimental Cores and provides leadership for the Metabolomics Consortium. This work is innovative because it will exploit existing infrastructure and mechanisms at PNNL for immediate collaborations with and dissemination of PNACIC resources to the scientific community.