Factors impacting locomotor learning following stroke

项目摘要/摘要 中风通常会导致许多身体障碍，限制功能活动，使其成为主要原因 在美国长期残疾的人。康复专业人员和中风幸存者的主要目标 就是提高行走能力。尽管在改善行走方面做出了重大努力，但许多中风幸存者无法 中风后能独立行走。这在一定程度上是由于中风幸存者对 康复干预。因为运动学习是有效康复干预的基础， 中风后运动学习的可变性是这种可变性的一个来源。到目前为止，几乎没有 关于导致这种可变性的因素的信息，使定制中风后成为一项挑战 康复干预。之前的研究检查了人口统计信息和感觉运动 障碍是解释中风后运动学习变异性的潜在因素；然而，这些因素 还没有发现可以解释很大一部分变异性的原因。在健康的成年人中，认知已被发现 解释学习上肢任务的可变性，但这在走路或中风后还没有被研究过， 认知缺陷很常见的地方。因此，该提案的总体目标是确定两国关系 中风后认知和运动学习之间的关系。在目标1中，我们将考察 在中风幸存者中学习新的行走模式和流体认知。在目标2中，我们将考察两者之间的关系 在记忆新的行走模式(即保持)和中风幸存者的流畅认知之间。这个 该项目的结果将解决我们对中风后运动学习的理解上的关键差距，并允许 我们需要更好地定制康复干预措施，以优化中风后的预后。此外，这项提议 工作是迈向这位奖学金申请者长期目标的第一步，那就是成为一个 成功的临床科学家专注于开发个性化的康复干预措施，使 卒中后功能恢复。通过在经验丰富的指导下完成此奖学金提案 导师在一个强大的研究环境中，申请者将接受成功所需的培训 完成建议的工作，发展成为一名多产的科学家，并实现她的长期职业目标。

PROJECT SUMMARY/ABSTRACT Stroke often results in numerous physical impairments that limit functional mobility, making it the leading cause of long-term disability in the United States. A primary goal for rehabilitation professionals and stroke survivors is to improve walking abilities. Despite significant efforts to improve walking, many stroke survivors are unable to walk independently after their stroke. This is in part due to variability in how stroke survivors respond to rehabilitation interventions. Because motor learning is the foundation for effective rehabilitation interventions, variability in locomotor learning after stroke is one source of this variability. To date, there is almost no information on factors that account for this variability, making if challenging to customize post stroke rehabilitation interventions. Previous research has examined demographic information and sensorimotor impairments as potential factors to explain variability in locomotor learning after stroke; however, these factors have not been found to explain a significant portion of variability. In healthy adults, cognition has been found to explain variability in learning upper extremity tasks, but this has not been examined in walking or after stroke, where cognitive deficits are common. Thus, the overall goal of this proposal is to determine the relationship between cognition and locomotor learning after stroke. In Aim 1 we will examine the relationship between learning a new walking pattern and fluid cognition in stroke survivors. In Aim 2, we will examine the relationship between remembering the new walking pattern (i.e. retention) and fluid cognition in stroke survivors. The results of this project will address critical gaps in our understanding of locomotor learning after stroke and allow us to better customize rehabilitation interventions to optimize post stroke outcomes. Additionally, this proposed work serves as a first step towards the long-term goal of this fellowship applicant, which is to become a successful clinician scientist focused on developing personalized rehabilitation interventions that optimize functional recovery after stroke. By completing this fellowship proposal under the guidance of experienced mentors in a strong research environment, the applicant will receive the training needed to successfully complete the proposed work, to develop into a productive scientist, and to achieve her long term career goals.