Imaging Research Shared Resource

影像研究共享资源 项目摘要/摘要 影像研究共享资源(影像SR)是病例综合癌症的重要资产 中心(Case CCC)成员的研究，通过参与科学计划的广度和 反映在使用这一SR的调查人员的数量上。仅去年一年，就有超过45名调查人员，其中54% 是Case CCC成员，占总使用量的71%，在该中心的7个项目中有6个使用了 高级成像SR的使命是为所有癌症研究人员提供一系列全面的 临床前和临床成像能力，可提供癌症的活体和原位成像评估。这个 成像SR是一家机构设施，集成了最先进的和全面的成像功能 用于癌症动物模型，以及儿科和成人患者。使这些努力成为可能的是成像SR 已建立的运营和行政基础设施，包括设备齐全的临床前成像设施 现场动物收容所；研究专用的人体核磁共振扫描仪；以及研究放射化学 设施包括回旋加速器和多个热室。成像SR的具体目标是： 1.为癌症研究人员提供临床前和临床研究影像服务。 2.提供成像专业知识，以设计有效的癌症成像实验。 3.提供针对具体项目的定量图像分析能力。 4.合成用于PET肿瘤研究的常规和新型放射性示踪剂。 5.培训新用户正确和安全地操作成像系统。 在最后的审查中，成像SR被评为优秀到突出的优点。在整个当前供资周期中 (2012-2016)，影像服务中心为83名注册用户提供服务，其中48名(58%)为Case CCC 成员，代表Case CCC的所有7个项目。 成像SR还可以访问由该部门提供的所有成像资源 凯斯西储大学(CWRU)/克利夫兰大学医院(UH)放射科 医疗中心，包括多台临床影像扫描仪。更多临床前成像功能 位于克利夫兰诊所(CC)的勒纳研究所(LRI)，包括一个新的临床前 核磁共振扫描仪和多台活体生物发光和荧光扫描仪。总体而言，成像SR 为癌症研究人员提供了一个高效且经济高效的机会来全面评估 癌症发生和发展的途径以及新的治疗策略和方法 癌症早期检测的最终目标是改善治疗，延长癌症患者的寿命。

IMAGING RESEARCH SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Imaging Research Shared Resource (Imaging SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the number of investigators who use this SR. Last year alone, over 45 investigators, 54% of whom were Case CCC members, accounting for 71% of total usage, from 6 out of the Center’s 7 Programs used the SR. The mission of the Imaging SR is to provide all cancer investigators with a comprehensive array of preclinical and clinical imaging capabilities to deliver in vivo and in situ imaging assessments of cancer. The Imaging SR is an institutional facility integrating state-of-the-art and comprehensive imaging capabilities both for animal models of cancer, as well as pediatric and adult patients. Enabling these efforts is the Imaging SR’s established operational and administrative infrastructure including a fully equipped preclinical imaging facility with onsite animal housing; a research-dedicated human MRI scanner; as well as research radiochemistry facilities including a cyclotron and multiple hot cells. The Specific Aims of the Imaging SR are to: 1. Provide preclinical and clinical research imaging services to cancer investigators. 2. Provide imaging expertise to design effective cancer imaging experiments. 3. Provide project-specific quantitative image analysis capabilities. 4. Synthesize both conventional and novel radiotracers for PET cancer studies. 5. Train new users in the proper and safe operation of the imaging systems. At last review, the Imaging SR was rated Excellent to Outstanding Merit. Throughout the current funding cycle (2012-2016), the Imaging SR provided services to 83 registered users, 48 (58%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The Imaging SR also has access to the full breadth of imaging resources provided by the Department of Radiology at Case Western Reserve University (CWRU) / University Hospitals (UH) Cleveland Medical Center including multiple clinical imaging scanners. Additional preclinical imaging capabilities are housed at the Lerner Research Institute (LRI) at Cleveland Clinic (CC) including a new preclinical MRI scanner and multiple in vivo bioluminescence and fluorescence scanners. Overall, the Imaging SR presents an efficient and cost-effective opportunity for cancer investigators to comprehensively evaluate novel pathways in cancer initiation and progression as well as new therapeutic strategies and methodologies for early cancer detection with the ultimate goal of improved care and longer lives of cancer patients.