Neuroimaging Core (NI)

神经影像核心（NI）提供最先进的神经影像设施和方法。 COBRE基金将支持一名生物工程师（与BSTIM核心共享），他将监督技术方面的工作 并开发新的方法，将图像采集与刺激和康复技术相结合;一个完整的 时间图像技术员谁将提供培训和援助的分析和解释复杂的 测量; EEG技术员的部分工作，该技术员将提供高密度EEG技术指导 并协助数据分析;并致力于高级教师谁将提供指导和培训， 严谨性、再现性和解释以及人类和动物研究的方法开发。具体 目的是：（1）为COBRE研究者提供现代神经成像工具的交钥匙访问，以研究 脑卒中恢复相关的脑形态、连接、代谢和功能变化;（2）发展 创新的工具，以观察详细的神经反应（短期和长期），以不同的干预措施; 3） 生成高质量、可重复的定量数据，以帮助识别神经成像“生物标志物”， 成为形成大型多系统定量数据集的领导者，以纳入COBRE综合 多学科数据库（CMD）以及国家和国际数据共享工作;以及4）导师和 培训COBRE调查人员获取和分析复杂的神经成像数据，以便他们能够调查 利用内在的可塑性，开发和翻译基于经验的新机制， 介入方法朝着这些目标不断取得进展将使NI核心成为首要资源 在MUSC以及全国范围内， 化国际大NI Core将有助于研究人员获得结构和功能成像方法， 如血氧水平依赖（BOLD）磁共振波谱（MRS），动脉自旋标记（ASL）， 和高密度脑电图（EEG），使他们能够提出重要的研究问题， 与卒中相关的组织体积和适应性可塑性，卒中病理学，基础 代谢，细胞复杂性的局部估计，对局部脑刺激的区域反应， 相应的功能反应。NI核心的多模式，跨学科，综合性，鼓励 协同创新在扫描仪内使用经颅磁刺激的能力（即，交错 TMS/fMRI）使MUSC成为研究人员可以直接检查即时和更长时间的极少数地方之一- 脑刺激干预对脑活动和血液动力学的长期影响，并调查因果关系。 在大脑网络的皮层和皮层下节点中诱导活动的性质。此外，7 T小动物 扫描和双光子显微镜系统提供了灵敏的平移工具来研究机制 基础康复和皮层刺激增强动物神经可塑性和卒中恢复 模型

The Neuroimaging Core (NI) provides access to state-of-the art neuroimaging facilities and methodologies. COBRE funds will support a Bioengineer (shared with the BSTIM Core) who will oversee the technical aspects and develop new methods to interface image acquisition with stimulation and rehabilitation techniques; a full- time Image Technician who will provide training and assistance for analysis and interpretation of complex measurements; partial effort of an EEG Technician who will provide guidance in techniques for high density EEG and assist with data analyses; and dedicated effort for senior faculty who will provide mentoring and training in rigor, reproducibility and interpretation as well as methods development for human and animal studies. Specific aims are to: (1) Provide COBRE investigators with turnkey access to modern neuroimaging tools to investigate stroke-recovery related changes in brain morphology, connectivity, metabolism and function; (2) Develop innovative tools to observe the detailed neural response (both short- and long-term) to diverse interventions; 3) Generate high quality, reproducible, quantitative data to help identify neuroimaging “biomarkers” and thereby become a leader in forming large multi-system quantitative data sets for inclusion in the COBRE Comprehensive Multidisciplinary Database (CMD) as well as national and international data sharing efforts; and 4) Mentor and train COBRE investigators in the acquisition and analysis of complex neuroimaging data so they can investigate and exploit inherent plasticity and develop and translate novel mechanism-based, experience-dependent interventional methods. Continuous progress toward these aims will establish the NI Core as a premier resource in the integration of neuroimaging into stroke rehabilitation studies at MUSC, as well as nationally and internationally. The NI Core will facilitate investigators’ access to structural and functional imaging methods such as blood oxygen level dependent (BOLD) magnetic resonance spectroscopy (MRS), arterial spin labeling (ASL), and high density electroencephalography (EEG), enabling them to ask important research questions such as tissue volume associated with the stroke and adaptive plasticity, stroke pathology, correlates of basal metabolism, local estimates of cellular complexity, regional responses to localized brain stimulation and corresponding functional responses. The NI Core’s multimodal, cross-disciplinary, integrative nature encourages collaborative innovation. The ability to use transcranial magnetic stimulation within the scanner (i.e., interleaved TMS/fMRI) makes MUSC one of very few places where investigators can directly examine immediate and longer- term effects of brain stimulation interventions on brain activity and hemodynamics, and investigate the causal nature of induced activity in cortical and subcortical nodes of a brain network. In addition, 7T small animal scanning and two-photon microscopy systems provide sensitive translational tools to investigate mechanisms underlying rehabilitation and cortical stimulation enhancement of neural plasticity and stroke recovery in animal models.