Mapping and manipulating circuits for relapse and abstinence

酒精使用障碍和其他药物成瘾是慢性复发的情况。目前的治疗方法只有适度的疗效。真正的改善需要两方面的进步。首先是在细胞和神经回路水平上分析支持戒断和复发的大脑机制。第二种方法是以同样的精度治疗这些神经回路。该项目是第一个进步，为下一代疗法奠定了基础科学平台。

Alcohol-use disorders and other drug addictions are chronically relapsing conditions. Current treatment approaches have only modest efficacy. Two advances are needed for genuine improvement. The first is parsing the brain mechanisms supporting abstinence and relapse at cellular as well as circuit levels. The second is targeting these circuits therapeutically with the same precision. This project contributes to the first advance and lays a basic science platform for next generation therapeutics.