The Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)

 描述(由申请人提供)：人类基因组研究提供了对心、肺和血液(HLB)特征的新见解，并有机会将研究结果转化为临床和社区环境，用于疾病预防和健康促进。然而，仍然没有足够数量的HLB遗传流行病学家能够设计和实施多学科HLB遗传流行病学研究，将基因组测量方面的技术进步与尖端统计工具相结合，以促进对HLB特征和相关疾病在负担最重的人群中的基因组基础的了解。心、肺和血液特征遗传流行病学(或GenHLB)培训赠款通过提供HLB特征遗传流行病学的跨学科、集成和全面的指导，由一支优秀的研究导师团队提供跨学科、集成和全面的指导，其专业知识涵盖四个拟议的培训维度：HLB遗传流行病学；计算/方法；OMIC；以及文化、多样性和差异。培训计划将包括基于个人发展计划的正式教学；量身定做的指导；两个培训方面的研究经验；陈述；手稿和赠款准备；研究研讨会和座谈会；以及负责任的研究行为指导。GenHLB培训计划还将包括对培训计划的质量和有效性进行仔细评估，确保研究员具备成功成为未来HLB遗传流行病学研究领导者所需的能力和技能。这项为期五年的方案旨在在入门时支持四名研究员(两名博士后和两名博士后)，到2003年将增加到六名研究员(三名博士前和三名博士后)。在博士后研究员中，将寻求流行病学、人类遗传学、生物统计学、生物信息学、计算生物学、医学和应用数学方面的先前专业知识。博士前研究员将被要求攻读流行病学博士学位，专门从事HLB遗传流行病学。我们选择了国际知名的研究导师，他们拥有成熟的研究合作、独特的多学科培训环境和无与伦比的研究机会，这使我们处于非常有利的地位，能够领导这一新颖的培训计划，并培养出装备精良的下一代遗传流行病学领导者，他们将研究HLB特征和相关疾病的遗传基础。

 DESCRIPTION (provided by applicant): Human genome studies are providing fresh insights into heart, lung, and blood (HLB) traits, with opportunities for translation of research findings t clinical and community settings for disease prevention and health promotion. Yet, there remain an insufficient number of HLB genetic epidemiologists who can design and implement multidisciplinary HLB genetic epidemiology research that combines technological advances in genome measurement with cutting-edge statistical tools to advance understanding of the genomic basis of HLB traits and associated diseases in the most-burdened populations. The Genetic Epidemiology of Heart, Lung, and Blood Traits (or GenHLB) Training Grant responds to these research gaps by providing interdisciplinary, integrated, and comprehensive instruction in the genetic epidemiology of HLB traits from an outstanding team of research mentors with expertise spanning four proposed training dimensions: HLB genetic epidemiology; computation/methods; `OMICs; and culture, diversity, and disparities. The Training Program will encompass formal didactics based on an individual development plan; tailored mentorship; research experiences in two training dimensions; presentations; manuscript and grant preparation; research seminars and colloquia; and instruction in the responsible conduct of research. The GenHLB training program also will include careful evaluation of the quality and effectiveness of the Training Program, ensuring that fellows achieve the competencies and skills necessary for success as future HLB genetic epidemiology research leaders. The five-year program aims to support four (two pre-doctoral and two postdoctoral) fellows at initiation, increasing to six (three pre-doctoral and three postdoctoral) fellows in year 03. Among the postdoctoral fellows, prior expertise in epidemiology, human genetics, biostatistics, bioinformatics, computational biology, medicine, and applied mathematics will be sought. Pre-doctoral fellows will be required to pursue a doctoral degree in epidemiology, specializing in HLB genetic epidemiology. Our selection of internationally known research mentors with established research collaborations, unique and multidisciplinary training environment, and unparalleled research opportunities make us exceptionally well-positioned to lead this novel training program and develop the next generation of genetic epidemiology leaders who are well-equipped to investigate the genetic underpinnings of HLB traits and associated diseases.