Markers of androgen action, genetic variation and prostate cancer risk

这一提议旨在通过三个大型独立的前列腺癌流行病学研究来追踪一系列研究的证据，这些研究表明，在男性生命的不同时期，激素作用的遗传和非遗传标记与前列腺癌风险有关，这些研究被称为前列腺癌项目。主要目标是收集痤疮和手指比例的暴露数据，以及前列腺癌项目研究中4种激素途径中候选基因的常见遗传变异的基因型病例和对照。前列腺癌的已知危险因素只有年龄、种族和家族史。我们预计这个项目将阐明激素在前列腺癌中的作用，我们将确定前列腺癌风险的新标记和疾病侵袭性标记。这些结果将帮助我们确定哪些男性有患前列腺癌的风险，从而有针对性地进行筛查和监测，并制定预防策略。此外，它们也将成为研究治疗靶点的基础。

This proposal aim to follow up evidence from a number of studies that genetic and non-genetic markers of hormonal action in different periods of a man's life are associated with prostate cancer risk using a collection of three large, independent epidemiologic studies on prostate cancer named the Prostate Cancer Program. A principal objective is to collect exposure data on acne and digit ratio, and genotype cases and controls across the studies of the Prostate Cancer Program for common genetic variants in 4 candidate genes in the hormonal pathway. The established risk factors for prostate cancer are only age, race and family history. We anticipate that this project will cast light on the role of hormones in prostate cancer and that we will identify new markers of risk of prostate cancer and markers of disease aggressiveness. These outcomes will help us identifying men who are at risk for prostate cancer to target screening and surveillance, and plan prevention strategies. Furthermore, they will also form the basis for research on treatment targets.