NARMS expands surveillance of antimicrobial resistance in retail foods to Hawaii

项目摘要/摘要 抗菌素耐药性(AMR)是影响食品安全和公众健康的重要问题。 目前国家抗生素耐药性监测系统(NARMS)零售食品 监控一直集中在大陆，并未覆盖夏威夷州。统一通信 戴维斯建议与NARMS合作，在人口稠密和 夏威夷大火奴鲁鲁地区人口结构不同的地点。该项目的目标是 改善食品安全和保障公众健康将通过以下方式实现 遵循特定的目标。首先，该项目将把NARMS零售食品监督扩大到新的 夏威夷的地理位置。根据人口密度和人口多样性，我们 将确定火奴鲁鲁地区的四个地点(城市火奴鲁鲁、东火奴鲁鲁、珍珠城、 和外帕湖)作为NARMS的新的代表性地理位置。在这里的杂货店 将确定每月随机购买零售肉类和海鲜样本的地点。 第二，该项目将监测零售食品中不同病原体之间的AMR趋势。 火奴鲁鲁地区。我们将采购零售肉类(鸡肉、火鸡、猪肉、牛肉、小牛肉)和海鲜。 (虾、三文鱼)每月从上述地点的杂货店采集样本。我们 将根据NARMS的零售肉类协议和海鲜从样本中分离细菌 试点研究方案。细菌分离物将每月运往FDA进行抗菌治疗 药敏试验、全基因组测序等分析。第三，项目将进行 零售食品中AMR流行率的流行病学研究。我们将收集以下元数据 每个样本并确定细菌流行率与其AMR之间的关键联系(例如 单一或多种抗药性)和零售食品的种类、来源、类型和形式，声称 抗生素的使用和季节等。第四，该项目将在 向利益相关者和公众零售食品。我们将开发非专业出版物、外展材料、 和同行评议的出版物。在FDA的批准下，我们将向 农业和水产养殖业社区、兽医和公众。 通过实现这些具体目标，该项目将表征AMR在 夏威夷的零售食品。该项目将加强NARMS零售食品监督 并提高公众对零售食品中AMR的认识。该项目还将加强 联邦和州机构以及学术界在研究、检测、 监测和调查零售食品中与AMR有关的食源性疫情。 1

Project Summary/Abstract Antimicrobial resistance (AMR) is an important issue for food safety and public health. Currently the National Antimicrobial Resistance Monitoring System (NARMS) Retail Food Surveillance has been focusing on the mainland and has not covered the state of Hawaii. The UC Davis proposes to collaborate with NARMS to survey AMR in retail foods in populous and demographically-diverse locations in the Greater Honolulu Area of Hawaii. The project’s goal of improving food safety and protecting public health will be achieved by undertaking the following specific aims. First, the project will expand NARMS Retail Food Surveillance to new geographical locations in Hawaii. Based on population density and demographical-diversity, we will identify four locations in the Honolulu Area (Urban Honolulu, East Honolulu, Pearl City, and Waipahu) as NARMS’ new representative geographical locations. Grocery stores in these locations will be identified for randomly purchasing retail meat and seafood specimens monthly. Second, the project will monitor trends of AMR among different pathogens in retail foods in the Honolulu Area. We will purchase retail meat (chicken, turkey, pork, beef, veal) and seafood (shrimp, salmon) specimens monthly from grocery stores in the locations mentioned above. We will isolate bacteria from specimens according to NARMS’ Retail Meat Protocol and Seafood Pilot Study Protocol. Bacterial isolates will be shipped to FDA monthly for antimicrobial susceptibility test, whole genome sequencing, and other analysis. Third, the project will conduct epidemiological studies on the prevalence of AMR in retail foods. We will collect metadata for each specimen and determine key links between the prevalence of bacteria and their AMR (e.g. single or multiple drug resistance) and species, origins, types, and forms of retail food, claims of antibiotics use, and seasons etc. Fourth, the project will disseminate information of AMR in retail foods to stakeholders and the public. We will develop lay publications, outreach materials, and peer-reviewed publications. With FDA’s approval, we will disseminate the information to agriculture and aquaculture communities, veterinarians, and the public. By accomplishing these specific aims, the project will characterize the trends of AMR in retail foods in the state of Hawaii. The project will enhance NARMS Retail Food Surveillance and increase public awareness of AMR in retail foods. The project will also strengthen collaborations among federal and state agencies and academia on research, detection, surveillance, and investigation of foodborne outbreaks associated with AMR in retail food. 1