Osteoporotic Fractures in Men (MrOS) - Minneapolis

与年龄相关的骨骼、肌肉和体能的恶化，表现为骨质疏松症、骨质疏松症、 和残疾，是老年人发病和死亡的主要原因。当务之急是了解如何 肌肉骨骼表型和体力活动随着年龄的增长而变化，影响这些的因素 变化，以及变化如何影响临床上重要的健康结果。MROS是一项独特的前瞻性研究 在扩大我们对年龄相关变化的理解方面非常有成效的5994名老年男性 在肌肉骨骼健康方面。它始于2000年，包括广泛的纵向、客观、最先进的 评估骨骼、肌肉、体能、体力活动和健康结果，以及 生物显微镜和影像档案。我们建议扩大这些资源，让我们有一个全面和 对肌肉骨骼衰老和体力衰退的过程和后果的综合理解 对老年男性的活动进行了长达15年的研究。该项目的总体长期目标是识别男性 面临不良健康后果风险的人可能受益于预防措施和康复，发现新的 治疗和预防肌肉骨骼健康和活动量下降的目标，并改善我们的 对最佳衰老的理解(保持肌肉骨骼健康和活动水平超过 平均总体随访时间为15年)。具体地说，我们将利用我们的重复测量来定义年龄- 中国人肌肉骨骼健康、体能和体力活动表型的相关轨迹 以确定预测这些轨迹并对其做出贡献的因素。我们将检验假设 在肌肉骨骼健康方面的有利轨迹与较低的跌倒、骨折、 残疾和死亡率，以及与年龄有关的骨骼、肌肉和身体机能的退化 同时，联合恶化放大了不良功能和健康结果的风险。第二，我们 将使用我们重复的最先进技术来表征老年男性活动水平的变化和轨迹 问卷调查和客观评估加速度计的能量消耗。第三，我们将利用 将MRO与医疗保险索赔数据联系起来，以确定肌肉骨骼轨迹的关联 住院患者和疗养院相关卫生保健利用的表型和活动。第四，我们将审查 高分辨率下可能导致年龄相关性骨骼脆性的皮质骨的新特征 外周定量计算机断层扫描测量皮质孔隙度。我们将把它们的轨迹与 肌肉骨骼的健康和活跃度测量这些皮质骨，并测试皮质骨是否增加 孔隙度与裂缝有关。最后，我们将继续利用MRO作为新的科学和 对调查人员的培训。我们的申请与NIA和NIAMS的使命是一致的 与衰老过程和与肌肉骨骼衰老相关的疾病和状况有关的研究，以及 在这一科学领域培养新的研究科学家。

Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.