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Translational Neuroscience Core

Translational Neuroscience Core
转化神经科学核心
批准号:
9924009
负责人:
Mary E Blue
金额:
$14.29万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
已结题
起止时间:
至 2020-07-31

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中文摘要
翻译
翻译神经科学核心(核心D)的目标是为 导致智力和其他疾病的临床前(动物和人类)疾病模型的分析 并对相关的临床样本进行分析。这项工作的另一个主要目标 翻译神经科学的核心是促进将基本发现转化为临床试验。要实现 这些目标。Core D拥有在模拟动物发育障碍方面的专长的科学家, 能够执行其他地方无法获得的分析的专家,并且能够解开 导致智力残疾的生化/代谢机制。在许多研究中,调查人员 利用翻译神经科学核心对可视化对大脑的影响感兴趣。其中一个主要的 核心D的功能是提供培训和使用组织学和临床前成像设施。 另一个主要功能是提供一组针对代谢物和分子的高度专业化的分析 与智力和发育障碍有关。
英文摘要
The objective of the Translational Neuroscience Core (Core D) is to provide the best expertise possible to the analysis of preclinical (animal and human) models of disorders that lead to intellectual and other developmental disabilities, and to the analysis of relevant clinical samples. Another primary goal of this Translational Neuroscience Core is to facilitate the transfer of basic discoveries to clinical trials. To achieve these objectives. Core D has scientists with expertise in modeling developmental disorders in animals and experts who can perform assays that are not available elsewhere and that can unravel the biochemical/metabolic mechanisms that cause intellectual disability. For many of the studies, investigators utilizing the Translational Neuroscience Core are interested in visualizing effects on the brain. One of the major functions of Core D is to provide training and access to the Histology and Preclinical Imaging Facilities. Another major function is to provide a group of highly specialized assays that target metabolites and molecules of relevance to intellectual and developmental disorders.
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Targeted Therapies for Rett Syndrome
  • 批准号:
    9811146
  • 项目类别:
  • 资助金额:
    $43.48万
  • 财政年份:
    2019
  • 负责人:
    Mary E Blue
  • 依托单位:
Targeted Therapies for Rett Syndrome
  • 批准号:
    9916821
  • 项目类别:
  • 资助金额:
    $40.59万
  • 财政年份:
    2019
  • 负责人:
    Mary E Blue
  • 依托单位:
Dendrimer therapies for treatment of Rett Syndrome
  • 批准号:
    9334327
  • 项目类别:
  • 资助金额:
    $20.39万
  • 财政年份:
    2016
  • 负责人:
    Mary E Blue
  • 依托单位:
Dendrimer therapies for treatment of Rett Syndrome
  • 批准号:
    9235088
  • 项目类别:
  • 资助金额:
    $26.0万
  • 财政年份:
    2016
  • 负责人:
    Mary E Blue
  • 依托单位:
海外基金