Origins of Renal Physiology

项目摘要/摘要 MDI生物实验室寻求NIDDK R25支持第九至第十三届One- 肾脏研究员每周课程，肾脏生理学起源。课程将在九月的第一周举行。 2017年至2021年在缅因州巴尔港的MDI生物实验室园区。建议开设的课程 为肾脏研究员提供有关动态平衡基本概念的实践研究教育，并揭示 它们与构成肾脏生理学和肾脏学基础的经典实验有关。七道菜 提出了模块：肾小球滤过、近端小管功能、粗大上肢联合转运体、盐 分泌和平衡、集合管钠转运/ENaC、水平衡和酸/碱 动态平衡。七个模块中的每个模块在三个连续的两天的循环中运行(星期一到星期二， 周三-周四和周五-周六)，每次轮换的第一天都要进行密集的实验 第二天，向整个课程小组分析和介绍工作。每个人 学员将在三轮轮换中完成六个计划单元中的三个。以案例为基础的研究 在每一轮轮换之前，研究项目中的负责任行为将会出现。肾脏生理学的起源完全是 在国家肾脏短期课程中独一无二。该课程为参与者提供了研究工具，使他们 加深对生理动态平衡概念的理解，这在正常情况下是难以实现的 临床培训计划。该课程对肾脏研究员开放，自2010年以来，在有空间的基础上， 住院医师进入肾脏科。研究员和住院医生都从与老年人的密切互动中受益 领导课程模块的肾脏生理学研究人员。尤其是居民，通过与 来自不同项目的研究员分享他们对肾脏研究和肾脏病的见解。这门课是 在计量吸入器生物实验室网站(http://www.mdibl.org)，和J.Am最近的一篇社论中进行了描述 SoC。(Zeidel等人，JASN 19：649-50,2008)。申请的资金将用于支付课程学费和 参加者旅费；教职员工生活费、津贴和旅费；设施使用费；咨询服务；以及 管理研究教育计划所需的人员成本。

Project Summary / Abstract MDI Biological Laboratory seeks NIDDK R25 support for the ninth through thirteenth annual offerings of a one- week course for renal fellows, Origins of Renal Physiology. The course will be held the first week of September 2017 through 2021 on the MDI Biological Laboratory campus, in Bar Harbor, Maine. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Seven course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport /ENaC, water homeostasis, and acid/base homeostasis. Each of the seven modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday-Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the six planned modules during the three rotations. A case study-based Responsible Conduct in Research program will precede each rotation. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDI Biological Laboratory website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, stipends, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.