Translational Imaging Shared Resource

翻译成像共享资源(TISR)的总体使命是提供最先进的 为罗斯韦尔公园的研究人员提供临床前和翻译成像服务，以节省时间和成本- 举止得力。该资源为用户提供对高级成像设备的访问，包括磁力成像 磁共振成像(MRI)、超声(US)、光声成像(PAI)、荧光和生物发光 成像(BLI)。该资源由两名在临床前和临床方面拥有丰富经验的博士生领导。 成像，是布法罗200英里范围内唯一允许多模式解剖和 小动物和大动物疾病模型的功能成像。TISR总共为67名罗斯韦尔用户提供服务，其中 其中60名(90%)是CCSG成员，包括46名接受同行评审的CCSG成员和14名 CCSG成员没有经过同行审查，来自所有五个研究项目的资金，这些项目正在进行基础和 肿瘤学、放射学和癌症治疗学的翻译研究。这导致了4项专利和71项 同行评议的出版物，包括在顶级癌症和成像杂志上发表的几篇论文。在过去的5年中 多年来，TISR已经为41笔NIH拨款和6笔国防部拨款提供了成像服务。TISR还获得了两个奖项 NIH S10共享仪器授权支持扩展其成像服务，以包括最新的- 艺术光学和光声成像方法。该资源为癌症中心成员提供全天候访问 以及非侵入性成像技术应用方面的培训，以满足其癌症研究需求。这个 TISR的具体目标是：1)为罗斯威尔公园的调查人员提供接触体内最先进技术的途径 成像技术；2)开发定制成像协议和定量图像分析方案，以 在癌症的小动物和大动物模型上进行实验治疗的临床前试验；3)建立 一个技术平台，促进成像方法的临床翻译，以改进疾病检测和 对患者进行治疗监测。TISR业务的一个组成部分是持续评估 通过评估当前需求扩展和/或更新成像技术， 用户和癌症中心成员未来的预期研究需求。TISR的未来计划包括 升级现有的磁共振成像仪器，并扩大成像服务，使其包括PET/SPECT和CT。

The overall mission of the Translational Imaging Shared Resource (TISR) is to provide state-of-the-art preclinical and translational imaging services to investigators at Roswell Park in a time-efficient and cost- effective manner. The resource provides users access to advanced imaging modalities including magnetic resonance imaging (MRI), ultrasound (US), photoacoustic imaging (PAI), fluorescence and bioluminescence imaging (BLI). The resource is led by two PhD faculty with extensive experience in preclinical and clinical imaging, and is the only shared resource within 200 miles of Buffalo that allows for multimodal anatomic and functional imaging of small and large animal models of disease. TISR served a total of 67 Roswell users, of which 60 (90%) were CCSG members, including 46 CCSG members with peer reviewed funding and 14 CCSG members without peer reviewed funding from all five research programs who are conducting basic and translational investigations in oncology, radiology and cancer therapeutics. This has led to 4 patents and 71 peer-reviewed publications including several publications in top-tier cancer and imaging journals. In the past 5 years, TISR has provided imaging services for 41 NIH grants and 6 DoD grants. TISR was also awarded two NIH S10 shared instrumentation grants that enabled expansion of its imaging services to include state-of-the- art optical and optoacoustic imaging methods. The resource provides cancer center members 24/7 access to and training in the application of non-invasive imaging technologies for their cancer research needs. The specific aims of the TISR are to: 1) Provide Roswell Park investigators with access to state-of-the-art in vivo imaging technologies; 2) Develop customized imaging protocols and quantitative image analysis schemes to conduct preclinical trials of experimental therapeutics in small and large animal models of cancer; 3) Establish a technology platform that facilitates clinical translation of imaging methods for improved disease detection and therapy monitoring in patients. An integral part of TISR operations is the continual assessment of need for expanding and/or updating imaging technology through evaluation of current demand, feedback from existing users and anticipated future research needs of cancer center members. Future plans for TISR include upgrading the existing MRI instrumentation and expansion of imaging services to include PET/SPECT and CT.