Genomics Core

近三分之二的美国人口在临床上超重或肥胖，近10% 的人患有成人型糖尿病。路易斯安那州的发病率甚至更高， 这一事实为肥胖和糖尿病研究提供了公共卫生紧迫性， 在彭宁顿生物医学中心生物医学研究卓越中心的赞助下， 研究中心肥胖、糖尿病或代谢综合征的基础和临床研究 需要基因组学的方法来理解的分子机制， 各自的病理。PBRC COBRE的基因组学核心旨在促进这种 通过提供现代基因组学技术来进行调查，这些技术通常过于昂贵 供大多数实验室采购或维护。根据科学要求， COBRE和PBRC的研究人员，核心集中在“功能基因组学”， 基因表达测量和表观基因组学方法处于中心地位。具体 核心的目标是：（1）提供高质量和具有成本效益的基因组学技术 （2）为研究者提供必要的生物信息学分析和解释， 基因组学实验的框架，以及（3）作为智力和咨询资源 并促进对基因组学感兴趣的研究人员之间的互动和合作 接近。根据前两个供资期间生产率的良好记录， PBRC COBRE，基因组学核心的影响来自于促进研究的结果 进展，消除关键障碍，特别是在生物信息学领域， 通过与细胞生物学和生物成像核心的相互作用， 转基因核心，PBRC和COBRE研究人员。因此，基因组学核心是一个关键的 组成部分，以维持中心的基础和转化研究活动，并获得新的 校外支持

Nearly two-thirds of the US population is either clinically overweight or obese, and almost 10% of the population has adult-onset diabetes. Louisiana is afflicted with even higher incidence, a fact that provides the public health urgency for obesity and diabetes research conducted under the auspices of the Center of Biomedical Research Excellence at the Pennington Biomedical Research Center. Both basic and clinical research in obesity, diabetes, or metabolic syndrome requires genomics approaches to understand the molecular mechanisms that underlie the respective pathology. The Genomics Core of the PBRC COBRE seeks to facilitate such inquiries by providing access to modern genomics technologies that are typically too expensive for most individual laboratories to procure or to maintain. Based on the scientific requirements of COBRE and PBRC investigators, the Core has focused on `Functional Genomics', with measurements of gene expression and epigenomics approaches at center stage. The Specific Aims of the Core are (1) to make high quality and cost-effective genomics technology available to investigators, (2) to provide the bioinformatics necessary for the analytical and interpretative framework for genomics experiments, and (3) to serve as an intellectual and advisory resource and promote interactions and collaborations among investigators interested in genomics approaches. Based on a strong record of productivity in the prior two funding periods of the PBRC COBRE, the impact of the Genomics Core results from the facilitation of research progress, the removal of critical barriers, specifically in the realm of bioinformatics, and the creation of scientific synergy through interactions with the Cell Biology and Bioimaging Core, the Transgenic Core, and PBRC and COBRE investigators. Thus, the Genomics Core is a critical component to sustain the Center's basic and translational research activities, and obtain new extramural support.