Consortium for the study of chronic pancreatitis, diabetes and pancreatic cancer – Pittsburgh Clinical Center

摘要： 匹兹堡临床中心(PCC)是匹兹堡大学的一个临床-翻译项目 和UPMC旨在进行复发性急性胰腺炎(RAP)和慢性胰腺炎的研究 胰腺炎(CP)和增加纤维化、疼痛和胰源性疾病风险的因素 儿童和成人的糖尿病(T3cDM)和胰腺导管腺癌(PDAC)的风险 对于患有CP和/或DM的成人。匹兹堡大学和UPMC的多学科团队 被组织参与全面的临床、流行病学和生物学研究 胰腺疾病患者的特征和确定RAP的病理生理学 &CP及其后遗症。提出了三个具体目标：目标1.发展综合临床 集中核心流程以促进数据和生物样本管理，以最大限度地提高 交流和评估新技术。目的2.建立纵向模型 明确慢性阻塞性肺疾病演变过程中患者的研究队列。目标3.生成并测试一个 分析影响RAP、可能的CP和明确的进展的风险因素的框架 CP，以及用于监测疾病状态和终点的临床有用的生物标志物。我们现有的和 建立完善、高效和有效的临床基础设施，以实现患者收益，样本 处理、疾病进展评估、数据管理和分析将支持 程序。丰富的临床体量，各关键领域的内科专家表现者，建立 在流行病学、遗传学、生理学、细胞生物学、成像、生物统计学和 生物信息学，以及所有相关的疾病亚型，以及临床和 成人和儿童的研究领域确保了持续的成功。强者的历史 PCC教职员工与许多优秀项目的合作和工作关系 其他大学也将为国家财团提供动力。

Abstract: Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies on recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and factors that increase the risk of fibrosis, pain, and pancreatogenic diabetes (T3cDM) in children and adults, and risk of pancreatic ductal adenocarcinoma (PDAC) in adults with CP and/or DM. Multi-disciplinary teams at the University of Pittsburgh and UPMC are organized to participate in comprehensive clinical, epidemiological and biological characterization of patients with pancreatic disorders and to define the pathophysiology of RAP & CP and their sequela. Three specific aims are proposed: Aim 1. To develop integrated clinical center core processes to facilitate data and biosample management, to maximize communication and to evaluate of new technologies. Aim 2. To establish a model longitudinal research cohort of patients during evolution of definite CP. Aim 3. To generate and test a framework to analyze risk factors affecting the progression of RAP, probable CP and definite CP, and clinically useful biomarkers to monitor disease state and endpoints. Our existing and well-established, efficient and effective clinical infrastructure for patient accrual, sample processing, disease progression assessment, data management and analysis will support the program. The rich clinical volume, expert physician phenotypers in all critical areas, established leadership in epidemiology, genetics, physiology, cell biology, imaging, biostatistics and bioinformatics, and all relevant disease subtypes, plus administrative authority in clinical and research areas for both the adult and children ensure continued success. The history of strong collaborations and working relationships of the PCC faculty with many outstanding programs at other universities will also provide momentum to the national consortium.