UT Southwestern O'Brien Kidney Research Core Center

项目摘要/摘要 使命和主题。 这是乔治·M·奥布莱恩肾脏研究核心中心在华盛顿大学的续签申请 达拉斯得克萨斯西南医学中心目前由内科教授Orson Moe博士领导 医学和生理学博士，德克萨斯大学西南分校肾脏科主任。的总体使命 该中心旨在促进基础科学家和临床研究人员之间的双向协同互动， 最大限度地优化肾脏研究人员的研究，鼓励和便利非肾脏研究人员进行研究 肾脏问题。我们的三个主题是：1。肾脏发育和遗传学。2.生理学和 病理生理学。3.慢性肾脏疾病及其并发症 需要中锋。 肾脏科学的发现正在以惊人的速度从不同的环境中涌现。没有单程票。 实验室或研究人员可以通过开发将他们的发现转化为全面的生物学说明，并最终 临床应用。肾脏领域以外的研究人员经常有与肾脏相关的有趣发现。 疾病，但由于缺乏知识、试剂、模型和技术，缺乏追踪发现的能力。 这一差距需要弥合，这样才不会错过发现的机会，我们还可以增加 肾脏研究人员的数量。在肾脏研究界，基础科学家需要适当和 广泛的表型分析，将他们的发现转化为临床应用。临床研究人员也需要板凳 澄清临床结果以阐明机制，并建立强大的系统来发现新的生物标志物和 治疗。双向翻译是我们中心的中心宗旨。我们的最终目标是提高诊断率 和治疗肾脏疾病。 中心成员数量和直接成本。 我们中心有12名中心成员，他们是德克萨斯大学西南分校的教职员工，在内部和直接拥有头衔 由奥布莱恩中心支持。我们有254名核心会员，他们是奥布莱恩的校内外用户 中心。申请的直接费用约为每年749,000美元。该中心由肾科资助。 而德克萨斯大学西南分校的实际运营成本实际上超过了允许的预算。 研究基地、生物医学核心、P&F计划和浓缩计划概述。 该中心支持所有与肾功能和疾病有一定关系的研究。许多基础科学家 致力于高度基础的生物学问题，如动脉粥样硬化、自噬、细胞蛋白运输 糖尿病，发现使用肾脏作为模型系统的科学价值，我们很高兴我们能吸引这样的人 调查人员到肾脏进行调查。我们通过三个门户-基础设施支持、教育和财政-履行我们的职责 支持先行先试。 生物医学研究核心。设计了四个核心，以提供跨越整个跨度的基础架构 双向翻译。(A)动物核心还分发和帮助产生转基因小鼠 AS创建了疾病模型，通过另外两个核心进行完整的表型鉴定。(B)生理学核心提供功能 表型分型使研究各种整体生物体功能成为可能。(C)细胞生物学、病理学和 成像核心支持从整个有机体到单个细胞的解剖和功能表型。(D) 临床翻译核心促进了结果的双向翻译，以实现我们的目标。 浓缩计划。我们通过几种方式提供教育。我们每两个月举办一次系列研讨会 校园内的讲师以及特邀演讲者涵盖了肾功能和疾病的许多方面。在……里面 此外，我们每年举行一次研讨会，由该领域的顶尖专家讨论特定主题。我们的 生物医学核心还为研究人员提供理论和技术培训。最后，我们的奥布莱恩中心 主持几个暑期项目，以教育和激励学生参与肾脏研究。 试点和可行性计划。在假设检验的初步阶段，调查人员往往没有 为申请校外拨款提供足够的资料。我们的P&F计划资助初级调查人员或 高级调查人员考虑偏离他们的轨迹，冒险进入肾脏研究。我们有一个 以前的受赠人提交和获得赠款的良好记录。 概述的机制有助于美国和国外的大量研究人员在肾脏方面取得进展 发育和遗传学、生理学和病理生理学以及慢性肾脏疾病，以促进 人类肾脏疾病的诊断和治疗。

PROJECT SUMMARY/ABSTRACT Mission and themes. This is an application for renewal of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas currently directed by Dr. Orson Moe who is Professor of Internal Medicine and Physiology, and Chief of the Division of Nephrology at UT Southwestern. The overall mission of the Center is to promote bidirectional synergistic interactions between basic scientists and clinical researchers, maximally optimize research for renal investigators, and encourage and facilitate non-renal researchers to study renal questions. Our three main themes are: 1. Kidney development and genetics. 2. Physiology and pathophysiology. 3. Chronic kidney disease and its complications Need for Center. Discoveries in renal science is emerging at an alarming rate and from diverse circumstances. No single laboratory or investigator can take their findings through development into full biologic elucidation and eventual clinical applications. Researchers outside the renal field often make interesting findings pertinent to kidney disease but lack the ability to pursue the finding due to lack of knowledge, reagents, models, and techniques. This gap needs to be bridged so opportunities of discovery will not be missed, and we can also increase the number of renal investigators. Within the renal research community, basic scientists need appropriate and extensive phenotyping, to translate their findings to clinical application. Clinical researcher also need bench clarification of clinical findings to elucidation mechanisms, and robust systems to discover new biomarkers and treatment. Bidirectional translation is a central purpose of our Center. Our ultimate goal is to improve diagnosis and treatment of kidney diseases. Number of Center Members and Direct Cost. Our Center houses 12 Center Members, which are UT Southwestern faculty holding a title within and directly supported by the O'Brien Center. We have 254 Core Members, who are on or off campus users of the O'Brien Center. The direct cost requested is about $749,000 per year. The Center is subsidized by the Renal Division and by UT Southwestern so the real operating cost actually exceeds the allowed budget. Overview of research base, Biomedical Cores, P&F Program and Enrichment Program. The Center supports all research with some relationship to kidney function and disease. Many basic scientists work on highly fundamental biologic problems such as atherosclerosis, autophagy, cellular protein trafficking, diabetes, find scientific merit in using the kidney as model systems and we are delighted that we can attract such investigators to renal investigation. We fulfil our role via three portals- infrastructure support, education, and fiscal support to jumpstart pilot projects. Biomedical Research Cores. Four Cores are designed to provide the infrastructure to bridge the full span for bidirectional translation. (A) The Animal Core distributes and helps generate genetically modified mice as well as create disease models for full phenotyping by two other Cores. (B) The Physiology Core provides functional phenotyping enabling the study of a wide variety of whole organism function. (C) Cell Biology, Pathology, and Imaging Core supports anatomic and functional phenotyping from the whole organism to the single cell. (D) The Clinical Translational Core facilitates bidirectional translation of findings to fulfil our objective. Enrichment Program. We provide education through several means. We have a bimonthly seminar series with lecturers on campus as well as invited speakers to cover many aspects of kidney function and disease. In addition, we have an annual Symposium where specific topics are covered by leading experts in the field. Our Biomedical Cores also provide theoretically and technical training to investigators. Finally, our O'Brien Center hosts several summer projects to educate and motivate students to enter renal research. Pilot and Feasibility Program. In the preliminary phase of hypothesis testing, investigators frequently do not have adequate data for extramural grant application. Our P&F program funds two grants from junior investigators or senior investigators considering an excursion from their trajectory to venture into kidney research. We have an excellent track record of previous grantees submitting and obtaining grants. The mechanisms outlined serves a large body of investigators in the US and abroad to make advances in kidney development and genetics, physiology and pathophysiology, and chronic kidney disease, to advance the diagnosis and treatment of human kidney disease.