International Symposium of ALPD and Cirrhosis

 描述(由申请人提供)：本R13续期申请旨在为2016、2018和2020年举行的第11~13届酒精性肝胰腺疾病(ALPD)和肝硬变国际研讨会提供支持。从2011年开始，R13赠款机制支持在日本、中国、印度和匈牙利举行的研讨会，并将于2015年9月在巴西举行。这些会议由10-15个国家代表参加，每次活动吸引257-475人参加。总共召集了236名演讲者、讨论者和主持人；发布了226张海报；并提供了83个旅行奖项，将青年科学家和学生吸引到这个国际平台上来。每一次专题讨论会都出版了一期特刊，其中包括关于发言者所涉专题的评论文章，总共96篇文章发表在增刊上。这些会议促进了具有互补专业知识和资源的研究人员之间积极的国际合作，产生了11份同行审查出版物和获得了三笔赠款，并导致了ALPD和肝硬变领域的重大科学进步。研讨会的总体具体目标仍然是：1)促进不同学科和国家之间的国际合作；2)分享各国现有的互补资源和专门知识，从而增加协同作用和独特的想法；3)鼓励青年研究人员在国际一级进行交流；以及4)促进向专业和非专业社区传播有助于预防和治疗疾病的新的科学和翻译信息。第11次会议将作为在德国柏林举行的ISBRA/ESBRA-2016联合世界大会的卫星举行，第12次会议将作为在日本京都举行的ISBRA-2018的卫星举行。第13次会议将在韩国与韩国肝脏研究协会(KASL)的东道主举行。每一次会议都将有一个独特的科学会议总主题和分主题。第11次会议的初步计划围绕ALPD的免疫学、肝和胰腺癌与肝硬变的新疗法、肝脏疾病和癌症中的CYP2E1、ADH和ALDH，以及涉及肠道微生物量的系统生物学等主题制定。这笔NIAAA R13赠款将支付受邀美国演讲者的差旅费用，并为美国年轻调查人员提供差旅奖励，同时主办组织预计将为场地和会议后勤提供匹配支持，以及来自非美国和主办国的受邀演讲者和年轻与会者的差旅。这种分担财务责任的机制将确保具有成本效益的会议管理，而不影响科学和外联的协同成果。

 DESCRIPTION (provided by the applicant): This R13 renewal application seeks support for the 11th~13th International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD) and Cirrhosis to be held in 2016, 2018, and 2020. From 2011, the R13 grant mechanism supported the symposia held in Japan, China, India, and Hungary and to be held in Brazil in September of 2015. These meetings were represented by 10-15 nations and attracted the attendance of 257-475 per event. Total 236 speakers, discussants, and moderators have been assembled; 226 posters were presented; and 83 travel awards were offered to bring young scientists and students to this international platform. Each symposium has resulted in publication of a special issue encompassing review articles on the topics covered by the speakers with total 96 articles published in supplement issues. The meetings have catalyzed active international collaborations among investigators with complementary expertise and resources, resulted in 11 peer-review publications and acquisition of three grants, and led to major advancements of science in the field of ALPD and cirrhosis. Overall specific aims of the symposia remain to be: 1) to promote international collaboration among different disciplines and nations; 2) to share the complementary resources and expertise available in various countries, thus adding synergy and unique ideas together; 3) to encourage young investigators to interact at an international level; and 4) to promote dissemination to professional and lay communities of new scientific and translational information which can be helpful for prevention and treatment of the diseases. The 11th meeting will be held as a satellite to the joint World Congress of ISBRA/ESBRA-2016 in Berlin, Germany and the 12th meeting as a satellite to ISBRA-2018 in Kyoto, Japan. The 13th meeting will be held in Korea with the host of the Korean Association for Study of the Liver (KASL). Each will have a unique general theme and subthemes for scientific sessions. A preliminary program for the 11th meeting has been created around the topics of immunology of ALPD, novel therapies of liver and pancreatic cancer and cirrhosis, CYP2E1, ADH, and ALDH in liver disease and cancer, system biology involving intestinal microbitota. This NIAAA R13 grant will defray travel costs of invited US speakers and to provide travel awards for US young investigators while the hosting organization is expected to provide a matching support for the venue and meeting logistics, as well as travel for invited speakers and young attendees from non-US and hosting nations. This mechanism of shared financial responsibility will assure cost-effective meeting management without compromising the synergistic outcome for science and outreach.