Developmental Research Program

项目摘要 胰腺癌发展研究计划（DRP）的目标是招募和 支持胰腺癌的发展研究项目，以便将来作为完整的SPORE项目纳入 或作为申请其他主要同行评审资金的基础。研究项目的类型 支持基础研究、临床研究、流行病学研究和癌症预防与控制， 胰腺癌项目将扩大转化研究的范围，增加 致力于胰腺癌研究的研究人员。该计划对所有机构开放 参与SPORE及其任何合作者。此外，计划要求开发新的 与其他项目合作。该计划，沿着职业提升计划，符合 Siteman癌症中心对招募少数民族和代表性不足的人的总体承诺 investigators.通过发展基金征集和资助新的研究项目。在本申请中， 在整个计划期间，每年将资助两至三个发展项目。 将要求胰腺癌研究开发项目的申请（RFA） 每年。所有开发项目申请将由研究开发顾问审查 委员会由具有胰腺癌领域专业知识的科学家（代表基础科学和应用科学）组成 癌症、生物统计学家、患者倡导者和特设成员（如有必要）（专业知识，无冲突 感兴趣）。该委员会将向胰腺癌孢子指导委员会提出建议。 该委员会将做出最终的资金决定。 相关性 这项工作的提出将导致更好地了解胰腺癌生物学，并将导致新的 在早期发现，预防，成像和治疗这种难治性恶性肿瘤的方法。

PROJECT SUMMARY The goal of the SPORE in Pancreatic Cancer Developmental Research Program (DRP) is to recruit and support developmental research projects in pancreatic cancer, for future incorporation as full SPORE projects or as the basis for applications for other major peer-review funding. The types of research projects to be supported basic research, clinical research, epidemiologic studies, and cancer prevention and control in pancreatic cancer. Projects will expand the scope of translational research and increase the number of investigators committed to pancreatic cancer research. This program is open to all of the institutions participating in the SPORE, and any of their collaborators. In addition, plans call for development of new projects with other SPOREs. This program, along with the Career Enhancement Program, is consistent with the Siteman Cancer Center's overall commitment to the recruitment of minority and underrepresented investigators. New research projects are solicited and funded through developmental funds. In this application, two to three developmental projects will be funded each year throughout the life of the SPORE. Requests for Applications (RFA) for developmental projects in pancreatic cancer research will be requested annually. All developmental project applications will be reviewed by a Research Development Advisory Committee consisting of scientists (representing basic and applied science) with expertise in pancreatic cancer, a biostatistician, a patient advocate, and ad hoc members, as necessary (special expertise, no conflict of interest). This committee will make recommendations to the Pancreatic Cancer SPORE Steering Committee, which will make final funding decisions. RELEVANCE The work proposed will lead to an improved understanding of pancreatic cancer biology and will lead to new approaches in early detection, prevention, imaging and treatment for this refractory malignancy.