Sample Repository for Human Genetic Research

NHGRI人类遗传学研究样本库 FOA标准杆-14-191 项目总结 NHGRI人类基因研究样本库提供了一个可访问的、 负担得起的、集中化的人类遗传学材料资源 在广泛的人群中进行的研究，用于生物医学研究。赞助商 NHGRI和科里尔医学研究所于2006年建立了这些藏品 在NHGRI库中包括来自国际HapMap项目的样本，1000 基因组计划、人类微生物组计划和用于分析的FOSMID文库 结构变化。NHGRI储存库的目标是刺激和促进 通过建立和维护一个高质量的、 未受污染的、特征良好的、记录良好的细胞系和DNA，并分发 将这些资源提供给世界各地的科学家和临床医生。NHGRI存储库示例是 为从事广泛研究的研究人员提供独特而宝贵的资源 了解人类基因组的结构和功能，包括对人类的研究 遗传变异及其与疾病易感性和其他共同特征的关联。 这些标准化资源是充分利用 人类基因组计划，以了解疾病的遗传起源。全国妇幼保健院 储存库的活动受高标准的质量管理，包括：(1)建立， 细胞系的表征、维护和分配，(2)制备、储存和 来自细胞系的DNA的分布，(3)定制的细胞球和DNA制剂的分布 应科学界的要求，(4)维护安全和全面的 数据库和在线目录；(5)宣传NHGRI资源库的藏品。目标 与NHGRI支持开发的使命是一致的 通过基因组传播加速基因组研究的资源和技术 向公众和卫生专业人员提供信息。

NHGRI Sample Repository for Human Genetic Research FOA PAR-14-191 PROJECT SUMMARY The NHGRI Sample Repository for Human Genetic Research provides an accessible, affordable, and centralized resource of well-characterized materials for human genetics research in a wide range of human populations for use in biomedical research. Sponsored by the NHGRI and established at the Coriell Institute for Medical Research in 2006, the collections in the NHGRI Repository include samples from the International HapMap Project, 1000 Genomes Project, Human Microbiome Project, and the Fosmid Library Collection for Analysis of Structural Variation. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic variation by establishing and maintaining a repository of high-quality, uncontaminated, well-characterized, and well-documented cell lines and DNA, and to distribute these resources to scientists and clinicians around the world. NHGRI Repository samples are a unique and valuable resource for investigators working on a broad range of studies aimed at understanding the structure and function of the human genome, including studies of human genetic variation and their association with disease susceptibility and other common traits. These standardized resources are critical elements in the efforts to take full advantage of the Human Genome Project for understanding the genetic origin of disease. The NHGRI Repository's activities are governed by high standards of quality and include: (1) establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage, and distribution of DNA from cell lines, (3) distribution of custom preparations of cell pellets and DNA as requested by the scientific community, (4) maintenance of a secure and comprehensive database and online catalog, and (5) publicizing the NHGRI Repository's collection. The goals of the Repository are consistent with the mission of the NHGRI to support development of resources and technology that accelerate genomic research through dissemination of genome information to the public and health professionals.