Human Physiology Core

人类生理学核心提供最先进的、经济高效的集中化服务，用于评估 生化分析、人体成分和能量代谢、胰岛素敏感性和β细胞功能， 和心血管功能，用于糖尿病相关研究。为此，核心坚持认为 测量、收集和提供质量控制数据，维护和提供基于网络的调度系统，以及 由训练有素的技术人员为广泛的措施和服务配备人员，以满足 满足小型试验性研究和学生项目直至大型R01级协议的需求。此外，核心还促进了 跨UAB校园的糖尿病多学科研究，并提供培训、建议和指导，以 学生、研究员和教职员工。最后，核心有助于开发、演变和扩展 通过实施和验证新的技术和方法，在UAB的糖尿病领域的方法学。新的 在此项目期间提供的技术包括用于评估组织和器官成分的“liverLab”软件 来自磁共振成像和光谱学。此次续订提供的新服务是对人力资源的支持 组织活检和睡眠/昼夜节律研究。因此，人类生理学核心促进了涉及人类的研究 志愿者包括糖尿病和心脏代谢性疾病患者。这是 DRC的整体研究计划涵盖了广泛的翻译领域，并努力寻找新的 治疗靶点，为临床预防和治疗糖尿病带来更好的治疗方法。

The Human Physiology Core provides state-of-the-art, cost-effective, centralized services for assessment of biochemical analytes, human body composition and energy metabolism, insulin sensitivity and beta-cell function, and cardiovascular function for diabetes-related research studies. Toward this end, the Core maintains instruments, collects and provides quality control data, maintains and offers a web-based scheduling system, and provides staffing by trained technical personnel for a broad suite of measures and services that can accommodate the needs of small pilot studies and student projects up to large R01-level protocols. In addition, the Core promotes multi-disciplinary research in diabetes across the UAB campus, and offers training, advice, and instruction to students, fellows, and faculty. Lastly, the Core contributes to the development, evolution, and expansion of methodology in field of diabetes at UAB by implementing and validating new technology and methodology. New technology offered in this project period includes “LiverLab” software for assessing tissue and organ composition from magnetic resonance imaging and spectroscopy. New services offered in this renewal are support for human tissue biopsy and sleep/circadian studies. Thus, the Human Physiology Core facilitates research involving human volunteers including patients with diabetes and cardiometabolic disease. This is an important component of the DRC’s overall research program which spans a broad translational spectrum and endeavors to identify new therapeutic targets and bring better treatments to the clinic in the prevention and treatment of diabetes.