Animal Physiology Core

动物生理学核心(APC)汇集了四位综合领域的专家 作为核心的生理学、心血管生理学、影像和动物模型 使用啮齿动物模型研究糖尿病的资源。这些方法和服务反映了 DRC的主题是糖尿病既是一种代谢性疾病，也是一种血管疾病。该计划的总体目标 APC将提供对高度专业化的设备和专业知识的轻松访问，以增强 糖尿病和心脏代谢研究的质量和成本效益。APC结合了 为新陈代谢和血管评估带来的专业知识和当前技术 集中在一个核心中，用于用户群的组合应用。 APC的具体目标是： 1.在糖尿病和心脏代谢性疾病动物模型的使用方面提供专业知识 研究； 2.提供最先进的人体测定仪器和方法 成分，能量平衡，葡萄糖平衡，心血管评估， 分子成像和转基因动物模型； 3.为核心用户提供符合成本效益的服务；以及 4.促进研究人员之间的互动，并提供动物模型和 表型鉴定方法。 自2008年刚果民主共和国APC成立以来，利用率和生产率的跟踪记录 一直很出色，而且还在不断增长。的高质量、广度和尖端特性 CORE的技术，以及对我们调查人员不断变化的需求的响应， 导致刚果民主共和国研究基地的使用率很高。通过发布高质量的 在小动物表型鉴定服务方面，核心是确保 研究在翻译研究的各个领域都得到了促进。生产力 核心利用率表中的数字和数据不言而喻。在上一次授予周期中， APC一直非常积极地支持糖尿病和心血管研究。这个 APC已经支持了来自77名UAB调查人员的145个资助项目。提供的数据 CORE成为众多联邦拨款的基础，并导致了许多高质量的出版物。

The Animal Physiology Core (APC) brings together four experts in the areas of integrative physiology, cardiovascular physiology, imaging, and animal models who serve as a core resource for the study of diabetes using rodent models. The methods and services reflect the DRC theme that diabetes is both a metabolic and vascular disease. The overall goal of the APC is to provide easy access to highly-specialized equipment and expertise to augment diabetes and cardiometabolic research quality and cost effectiveness. The APC incorporates expertise and current technology for both metabolism and vascular assessment, brought together in one core for combined applications by the user base. The Specific Aims of the APC are to: 1. Provide expertise in the use of animal models for diabetes and cardiometabolic disease research; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition, energy balance, glucose homeostasis, cardiovascular assessment, molecular imaging, and genetically modified animal models; 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the DRC APC was founded in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By promulgating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active in supporting diabetes and cardiovascular research. The APC has supported 145 funded projects from 77 UAB investigators. The data provided by the core became the basis of numerous federal grants and led to many high-quality publications.