National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project

项目摘要 本项目是根据RFA-AG-21-008制定的，描述了数据收集的核心计划， 全国青少年到成人健康纵向研究第六波（第六波）的传播 (Add健康），当队列成员年龄为39-48岁（平均44岁）时。Add Health是一项纵向研究， 在1994- 1995年期间，一个全国代表性的样本，包括20，000多名7-12年级的青少年， 一个学年，并已跟踪了五波至今。在过去的25年里，Add Health收集了丰富的 人口、社会、家庭、社会经济、行为、心理、认知和健康调查数据， 参与者和他们的父母;来自参与者学校，社区和 居住地;与参与者有关的行政数据，包括出生和死亡证明;以及 参与者的家庭物理和生物数据，包括人体测量，遗传标记， 血液检测和药物治疗辅助研究增加了更多的信息，包括表观遗传学， 基因表达和微生物组数据。因此，添加健康是非常独特的，因为它有一个丰富的，多- 水平，纵向阵列的数据为一个大型的全国代表性队列的美国人谁是进入 中年重要的是，这群人向中年过渡时的整体健康状况是有问题的 在许多方面。此外，不同种族、民族、性别、社会经济地位、性取向、 这一群体中的少数民族身份和城乡居住情况很普遍，在某些情况下，这种情况还在扩大。因此，Rich 迫切需要纵向、多层次和具有全国代表性的数据，以最好地了解生活 健康轨迹和美国成年人进入中年时的健康差异的过程决定因素。第六波 添加健康将满足这一关键需求。Add Health第六波的总体目标是收集和传播 需要全面的数据，以最好地了解社会，经济，心理，背景和生物 健康轨迹和差异的决定因素在这个全国代表性的美国人队列中， 他们会步入中年该项目主要围绕五个目标：1）使用 主要是基于网络和面对面的方式，明确注意确保高答复率， 少数民族和低社会经济地位的参与者; 2）丰富关键领域的研究内容， 将阐明中年和晚年的健康轨迹和差异; 3）重新访问同意的队列成员 用于家庭健康检查，包括静脉采血和其他重要的健康组成部分; 4） 分析生物样本的重要疾病前和疾病生物标志物;和5）清洁， 为科学界记录、传播、存档、推广和支持Wave VI数据。 该项目具有非凡的潜力，有助于老龄化，健康和健康差异的科学， 在未来的几十年里，随着添加健康队列进入中年及以后的年龄。成功执行 该项目的成果将为研究这些关键问题的数千名研究人员提供必要的数据。

Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when cohort members will be 39-48 years of age (mean 44). Add Health is a longitudinal study of a nationally representative sample of over 20,000 adolescents who were in grades 7-12 during the 1994-95 school year and have been followed for five waves to date. Over 25 years, Add Health has collected rich demographic, social, familial, socioeconomic, behavioral, psychosocial, cognitive, and health survey data from participants and their parents; a vast array of contextual data from participants' schools, neighborhoods, and geographies of residence; administrative data linked to participants, including birth and death certificates; and in-home physical and biological data from participants, including anthropometric measures, genetic markers, blood-based assays, and medications. Ancillary studies have added more information, including epigenetic, gene expression, and microbiome data. Thus, Add Health is exceptionally unique because it has a rich, multi- level, longitudinal array of data for a large nationally representative cohort of Americans who are entering midlife. Importantly, the overall health profile of the cohort as they make the transition to midlife is problematic across many dimensions. Moreover, health disparities by race, ethnicity, gender, socioeconomic status, sexual minority status, and rural-urban residence in this cohort are wide and, in some cases, widening. As such, rich longitudinal, multi-level, and nationally representative data are urgently needed to best understand the life course determinants of health trajectories and health disparities of US adults as they enter midlife. Wave VI of Add Health will fill this critical need. The overall goal of Wave VI of Add Health is to collect and disseminate the comprehensive data needed to best understand the social, economic, psychosocial, contextual, and biological determinants of health trajectories and disparities among this nationally representative cohort of Americans as they age into midlife. The project is focused around five aims: 1) Re-interviewing cohort members using predominantly web-based and in-person modes, with explicit attention to securing high response rates from racial/ethnic minority and low socioeconomic status participants; 2) Enriching study content in key domains that will elucidate mid- and later-life health trajectories and disparities; 3) Re-visiting cohort members who consent for an in-home health exam that includes venous blood collection and other important components of health; 4) Assaying biological specimens for important pre-disease and disease biomarkers; and 5) Cleaning, documenting, disseminating, archiving, promoting, and supporting Wave VI data for the scientific community. This project has extraordinary potential to contribute to the science of aging, health, and health disparities for decades to come, as the Add Health cohort ages into the middle adult years and beyond. Successful carryout of this project will supply essential data for thousands of researchers working on these critical issues.